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Two-way within-family and mass selection for 8-week body weight in different mouse populations

Published online by Cambridge University Press:  14 April 2009

Ines von Butler ,
Henning Willeke  and
Franz Pirchner
Ines von Butler
Affiliation:
Lehrstuhl für Tierzucht der TechnischenUniversität München 8050 Freising-Weihenstephan, FRG
Henning Willeke
Affiliation:
Lehrstuhl für Tierzucht der TechnischenUniversität München 8050 Freising-Weihenstephan, FRG
Franz Pirchner
Affiliation:
Lehrstuhl für Tierzucht der TechnischenUniversität München 8050 Freising-Weihenstephan, FRG
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Two mouse populations, randombred albino mice and a cross of four inbred strains, were divergently selected for high (H8) and low (L8) 8-week body weight over 18 generations using within-family and individual selection. The crossbreds showed asymmetry of selection response and realized heritabilities (H8 0·29 ± 0·01; L8 0·17 ± 0·01). In the randombred population realized heritabilities were symmetrical (H8 0·23 ± 0·01; L8 0·22 ± 0·02). Over the first nine generations individual selection was nearly 40 per cent better than within-family selection, as was expected from the full sib correlation in both populations. As selection progressed, within-family selection reached 82% and 61% of the responses obtained with individual selection in the crossbreds and randombred respectively. Correlated responses for 3-week (weaning) and 5-week body weights agreed with observations made on direct responses, but selection for L8 did not reduce weaning weight. Selection for L8 decreased and selection for H8 increased first litter size at birth. However, mass-selected L8-pairs had a higher life-reproduction and life-span than H8-pairs.

Type
Research Article
Information
Genetics Research , Volume 43 , Issue 2 , April 1984 , pp. 191 - 200
Copyright
Copyright © Cambridge University Press 1984

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