Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-27T01:37:54.395Z Has data issue: false hasContentIssue false

Transfer characteristics of two resistance determinants in a wild strain of Klebsiella aerogenes (V9A)

Published online by Cambridge University Press:  14 April 2009

E. C. R. Reeve
Affiliation:
Institute of Animal Genetics, West Mains Road, Edinburgh 9
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Klebsiella aerogenes strain V9A carries determinants AK and TK, giving resistance to ampicillin and tetracycline, and a plasmid FKlac, but no active sex factor. F− and I-type sex factors were able to transfer TK from V9A to Escherichia coli K12 and between strains of K12, and TK behaved as a separate plasmid with its own replicon. AK could not be transferred, except possibly by a sex factor carrying its own A determinant, but the evidence for such transfer was inconclusive. It is suggested that AK is either a chromosomal gene or is in a plasmid with a cell attachment in Klebsiella not represented in E. coli K12. AK produces a β-lactamase.

Type
Short Papers
Copyright
Copyright © Cambridge University Press 1970

References

REFERENCES

Anderson, E. S. (1968). The ecology of transferable drug resistance in the Enterobacteria. Annual Review of Microbiology 22, 131180.CrossRefGoogle ScholarPubMed
Anderson, E. S. & Lewis, M. J. (1965). Drug resistance and its transfer in Salmonella typhimurium. Nature, Land. 206, 579583.CrossRefGoogle ScholarPubMed
Cowan, S. T. & Steel, K. J. (1966) Manual for the identification of Medical Bacteria. Cambridge University Press.Google Scholar
Demerec, M., Adelberg, E. A., Clark, A. J. & Hartman, P. E. (1966). A proposal for a uniform nomenclature in factorial genetics. Genetics 54, 6176.CrossRefGoogle Scholar
Gillies, R. R. & Dodds, T. C. (1965). Bacteriology Illustrated. Edinburgh: Livingstone.Google Scholar
Lennox, E. S. (1955). Transduction of linked genetic characters of the host by bacteriophage. Virology 1, 190206.CrossRefGoogle ScholarPubMed
Reeve, E. C. R. & Braithwaite, J. A. (1970). FKlac, an episome with unusual properties found in a wild strain of a Klebsiella species. Nature, Lond. (in the Press).CrossRefGoogle Scholar
Vogel, J. H. & Bonner, D. M. (1956). Acetylornithinase of Escherichia coli: partial purification and some properties. Journal of Biological Chemistry 218, 97106.CrossRefGoogle ScholarPubMed