Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-23T01:30:50.958Z Has data issue: false hasContentIssue false
  • English
  • Français

Tich: a mutant causing disproportional growth in the mouse

Published online by Cambridge University Press:  14 April 2009

James R. Archer ,
Victoria A. Archer ,
Michael F. W. Festing  and
Mirian A. Ghiraldini
James R. Archer
Affiliation:
Bone, Tooth and Biomaterials Group, Bone and Joint Research Unit, London Hospital Medical College, London E1 2AD
Victoria A. Archer
Affiliation:
Britton's School, Rainham, Essex
Michael F. W. Festing
Affiliation:
MRC Toxicology Unit, Woodmansterne Road, Carshalton, Surrey
Mirian A. Ghiraldini
Affiliation:
Escola Paulista de Medicina, São Paulo, Brazil
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A spontaneous mutation ‘tich’ (gene symbol tch) appeared as a recessive mutation in inbred mice of strain A. TL. Homozygotes are rather dumpy mice of approximately normal weight but with short limbs and tail. Skeletal measurements on backcross siblings show that the mandible bones are almost normal but long bones and some parts of the pelvic and pectoral girdles are short. Although tich resembles brachypodism phenotypically it is not linked to agouti, and does not match the description of any other skeletal mutation. There was some evidence for weak linkage with albinism on chromosome 7. The mutation has reappeared amongst the A. TL mice of a UK commercial breeder and may have been accepted as the norm for A. TL amongst some European users of this mouse.

Type
Research Article
Information
Genetics Research , Volume 57 , Issue 1 , February 1991 , pp. 29 - 35
Copyright
Copyright © Cambridge University Press 1991

References

Archer, J. R., Smith, D. A., Davies, D. A. L. & Staines, N. A. (1974). A skingraft enhancing antiserum which recognises two new B cell alloantigens determined by the major histocompatibility locus of the mouse. Journal of Immunogenetics 1, 337–344CrossRefGoogle Scholar
Dixon, W. J. & Morgan, F. J. (1983). Introduction to Statistical Analysis, 4th edn.London, New York: McGraw-Hill International Book Co.Google Scholar
Festing, M. F. W. & Roderick, T. H. (1989). Correlation between genetic distances based on single loci and on skeletal morphology in inbred mice. Genetical Research 53, 45–55CrossRefGoogle ScholarPubMed
Green, E. L. (1981). Genetics and Probability in Animal Breeding Experiments. London, Basingstoke: Macmillan Publishers Ltd.CrossRefGoogle Scholar
Green, M. C. (1989). Catalog of mutant genes and polymorphic loci. In Genetic Variants and Strains of the Laboratory Mouse (ed. Lyon, M. F. and Searle, A. G.), pp. 12–403. Oxford, New York: Oxford University Press.Google Scholar
Wikström, B., Wallace, M. E., Hjerpe, A. & Engfeld, B. (1987). Chubby: a new autosomal recessive skeletal mutation producing dwarfism in the mouse. Journal of Heredity 78, 8–14.CrossRefGoogle ScholarPubMed