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Tetrapyrrole biosynthesis: N-methyl-N′-nitrosoguanidine-induced mutants of Propionibacterium shermanii

Published online by Cambridge University Press:  14 April 2009

N. H. Georgopapadakou ,
J. Petrillo ,
A. I. Scott  and
B. Low
N. H. Georgopapadakou
Affiliation:
Chemistry Department, Yale University, New Haven, Connecticut 06520
J. Petrillo
Affiliation:
Chemistry Department, Yale University, New Haven, Connecticut 06520
A. I. Scott
Affiliation:
Chemistry Department, Yale University, New Haven, Connecticut 06520
B. Low
Affiliation:
Radiobiology Laboratories, Yale University School of Medicine, New Haven, Connecticut 06510
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Summary

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An isolation method for N-methyl-N′-nitrosoguanidine-induced catalase negative mutants of P. shermanii based on replica plating is described. In contrast to previous methods, it extends to the early stages of tetrapyrrole biosynthesis which are common in both corrins and porphyrins. It may thus aid in elucidating the mechanism and control of porphyrin and corrin biosynthesis. Some preliminary results are discussed.

Type
Short Papers
Information
Genetics Research , Volume 28 , Issue 1 , August 1976 , pp. 93 - 100
Copyright
Copyright © Cambridge University Press 1976

References

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