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Tests of hypotheses on recombination frequencies

Published online by Cambridge University Press:  14 April 2009

N. E. Morton ,
C. J. MacLean  and
R. Lew
N. E. Morton
Affiliation:
Population Genetics Laboratory, University of Hawaii, Honolulu, HI 96822
C. J. MacLean
Affiliation:
Population Genetics Laboratory, University of Hawaii, Honolulu, HI 96822
R. Lew
Affiliation:
Population Genetics Laboratory, University of Hawaii, Honolulu, HI 96822
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Summary

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Data from Neurospora, Drosophila, and the mouse support the mapping parameter conventionally used for man, exclude the Haldane, Kosambi, and Carter—Falconer functions, and suggest a refinement for centromere mapping. Different sexes, chromosome arms, and types of data are surprisingly consistent. Double recombination frequencies are accurately predicted, but triple recombination frequencies are overestimated. The centromere appears to act on interference as an obligatory chiasma. Recombination across the centromere conforms to a simple approximation, based on the interval Markov assumption with a common mapping parameter. These results imply that mapping of n loci requires estimation of at most n parameters, and the relation between map distances and all recombination frequencies is explicit.

Type
Research Article
Information
Genetics Research , Volume 45 , Issue 3 , June 1985 , pp. 279 - 286
Copyright
Copyright © Cambridge University Press 1985

References

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