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Test for sex-linked lethals in irradiated mice

Published online by Cambridge University Press:  14 April 2009

C. Auerbach ,
D. S. Falconer  and
J. H. Isaacson
C. Auerbach
Affiliation:
Institute of Animal Genetics, Edinburgh, 9
D. S. Falconer
Affiliation:
Institute of Animal Genetics, Edinburgh, 9
J. H. Isaacson
Affiliation:
Institute of Animal Genetics, Edinburgh, 9
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Tabby males were irradiated with 500 r and mated to Bn Mobr♀♀. Daughters conceived during the first 3 weeks after irradiation were tested for the presence of sex-linked recessive mutations in their progeny, each daughter representing one irradiated gamete. One visible, but no lethal, was found in the Bn–Mobr segment among 154 tested gametes; one gamete was proved free of lethals or visibles in the Bn–Ta segment, and 21 gametes in the Ta–Mobr segment. Among the whole 176 tested gametes there was no indication of a lethal in the adjoining segments.

Type
Research Article
Information
Genetics Research , Volume 3 , Issue 3 , November 1962 , pp. 444 - 447
Copyright
Copyright © Cambridge University Press 1962

References

REFERENCES

Auerbach, C. & Moser, H. (1953). Analysis of the mutagenic action of formaldehyde food. II. The mutagenic potentialities of the treatment. Z. indukt. Abstamm. u. VererbLehre. 85, 547–563.Google ScholarPubMed
Berg, R. L. (1937). The relative frequency of mutations in different chromosomes of Drosophila melanogaster. I. Lethal mutations. Genetics, 22, 225–240.CrossRefGoogle ScholarPubMed
Carter, T. C. (1955). The estimation of total genetical map lengths from linkage test data. J. Genet. 53, 21–28.Google Scholar
Carter, T. C. (1956). The detection of autosomal lethals in mice induced by mutagenic agents. J. Genet. 54, 327–342.Google Scholar
Carter, T. C. (1957 a). Recessive lethal mutation induced in the mouse by chronic γ-irradiation. Proc. roy. Soc. B, 147, 402–411.Google ScholarPubMed
Carter, T. C. (1957 b). The use of linked marker genes for detecting recessive autosomal lethals in the mouse. J. Genet. 55, 585–597.CrossRefGoogle Scholar
Carter, T. C. (1959). A pilot experiment with mice, using Haldane's method for detecting induced autosomal recessive lethal genes. J. Genet. 56, 353–362.CrossRefGoogle Scholar
Carter, T. C. & Lyon, M. (1961). An attempt to estimate the induction by X-rays of recessive lethal and visible mutations in mice. Genet. Res. 2, 296–305.CrossRefGoogle Scholar
Falconer, D. S. (1954). Linkage in the mouse: the sex-linked genes and ‘rough’. Z. indukt. Abstamm.- u. VererbLehre. 86, 263–268.Google ScholarPubMed
Falconer, D. S. & Isaacson, J. H. (1962). The genetics of sex-linked anaemia in the mouse. Genet. Res. 3, 248–250.CrossRefGoogle Scholar
Haldane, J. B. S. (1960). The interpretation of Carter's results on induction of recessive lethals in mice. J. Genet. 57, 131–136.CrossRefGoogle Scholar
Phillips, R. J. S. (1954). Jimpy, a new totally sex-linked gene in the house mouse. Z. indukt. Abstamm.- u. VererbLehre. 86, 322–326.Google Scholar
Russell, W. L. (1951). X-ray induced mutations in mice. Cold Spr. Harb. Symp. quant. Biol. 16, 327–336.CrossRefGoogle ScholarPubMed
Russell, W. L., Bangham, Jean W. & Gower, Josephine S. (1958). Comparison between mutations induced in spermatogonial and postspermatogonial stages in the mouse. Proc. Xth int. Congr. Genet. Montreal, II, 245–246.Google Scholar
Russell, W. L. & Russell, Liane Brauch (1959). The genetic and phenotypic characteristics of radiation-induced mutations in mice. Rod. Res. Suppl. 1, 296–305.CrossRefGoogle Scholar