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Temperature-sensitive paralytic mutations on the second and third chromosomes of Drosophila melanogaster

Published online by Cambridge University Press:  14 April 2009

Shankar J. Kulkarni  and
Asha Padhye
Shankar J. Kulkarni
Affiliation:
Molecular Biology Unit, Tata Institute of Fundamental Research, Bombay, India
Asha Padhye
Affiliation:
Molecular Biology Unit, Tata Institute of Fundamental Research, Bombay, India
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Summary

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Seven temperature-sensitive paralytic mutants were recovered from 4544 lines of ethylmethanesulphonate (EMS) treated autosomes in Drosophila melanogaster. These mutants have been designated temperature-induced paralytic (tip). The tip mutations belong to six different genes; four of these, tip-A, Tip-B, tip-C and tip-D are on the second chromosome while tip-E and tip-F are on the third chromosome. This paper describes the paralysing behaviour and genetic localization of the tip mutants.

Type
Research Article
Information
Genetics Research , Volume 40 , Issue 2 , October 1982 , pp. 191 - 199
Copyright
Copyright © Cambridge University Press 1982

References

REFERENCES

Gethman, R. (1974). Meiosis in male Drosophila melanogaster. I. Isolation and characterization of meiotic mutants affecting second chromosome disjunction. Genetics 78, 1127–1142.CrossRefGoogle Scholar
Griggliatti, T. A., Hall, L., Rosenbluth, R. & Suzuki, D. T. (1973). Temperature-sensitive mutations in Drosophila melanogaster. XIV. A selection of immobile adults. Molecular and General Genetics 120, 107–114.CrossRefGoogle Scholar
Ikeda, K., Ozawa, S. & Hagiwara, S. (1976). Synaptic transmission reversibly conditioned by single gene mutation in Drosophila melanogaster. Nature 259, 489–491.Google Scholar
Lewis, E. B. & Bacher, F. (1968). Method of feeding ethyl-methanesulphonate (EMS) to Drosophila males. Drosophila Information Service 43, 193.Google Scholar
Lindsley, D. L. & Grell, E. H. (1968). Genetic variations of Drosophila melanogaster. Carnegie Institute of Washington Publications 627.Google Scholar
Poodry, C., Hall, L. & Suzuki, D. T. (1973). Developmental properties of shibire ts–1 a pleiotropic mutation producing larval and adult paralysis. Developmental Biology 32, 373–386.CrossRefGoogle Scholar
Siddiqi, O. & Benzer, S. (1976). Neurophysiological defects in temperature-sensitive paralytic mutants of Drosophila melanogaster. Proceedings of the National Academy of Sciences U.S.A. 73, 3253–3257.CrossRefGoogle ScholarPubMed
Singh, S. & Siddiqi, O. (1981). torpid A new sex linked paralytic mutation in Drosophila melanogaster. Molecular and General Genetics 181, 400–403.CrossRefGoogle ScholarPubMed
Suzuki, D. T., Griggliatti, T. & Williamson, R. (1971). Temperature-sensitive mutations in Drosophila melanogasler. VII. A mutation (parats) causing reversible adult paralysis. Proceedings of the National Academy of Sciences U.S.A. 68, 890–893.CrossRefGoogle Scholar
Wu, C. F. & Ganetzky, B. (1980). Genetic alteration of nenre membrane excitability in temperature-sensitive paralytic mutant of Drosophila melanogaster. Nature 286, 814–816.Google Scholar
Wu, C. F., Gantezky, B., Jan, L. Y., Jan, Y. N. & Benzer, S. (1978). A Drosophila mutant with a temperature-sensitive block in the nerve conduction. Proceedings of the National Academy of Sciences U.S.A. 75, 4047–4051.CrossRefGoogle ScholarPubMed