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A system generating spontaneous intrachromosomal changes at mitosis in Aspergillus nidulans

Published online by Cambridge University Press:  14 April 2009

B. H. Nga  and
J. A. Roper
B. H. Nga
Affiliation:
Department of Genetics, University of Sheffield
J. A. Roper
Affiliation:
Department of Genetics, University of Sheffield
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Previous studies had shown that haploid strains of Aspergillus nidulans which have a chromosome segment in duplicate are unstable at mitosis. Through the study of various haploid and diploid strains, with and without translocations and with balanced and unbalanced genomes, it has been shown: (1) that imbalance of chromosome segments is responsible for instability, and (2) that the chromosomal deletions produced are confined solely or largely to the segments which provoke instability.

The term ‘mitotic non-conformity’ has been proposed for this instability phenomenon. An explanation for it has been sought in terms of attachment sites, limited in number and specific for chromosome segments, at which replication is initiated.

Type
Research Article
Information
Genetics Research , Volume 14 , Issue 1 , August 1969 , pp. 63 - 70
Copyright
Copyright © Cambridge University Press 1969

References

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