Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-26T23:27:33.008Z Has data issue: false hasContentIssue false
  • English
  • Français

A super-suppressor on the thirteenth linkage group in Saccharomyces*

Published online by Cambridge University Press:  14 April 2009

Yasuji Oshima  and
Ikue Oshima
Yasuji Oshima
Affiliation:
Biological Research Laboratory, Southern Illinois University, Carbondale, Illinois
Ikue Oshima
Affiliation:
Biological Research Laboratory, Southern Illinois University, Carbondale, Illinois
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

It has been proved that the suppression of seven different auxotrophic mutant alleles is brought about by a single super-suppressor allele designated S. Super-suppressor S is allele-specific rather than locus-specific and is dominant to its wild-type allele.

Suppressible mutant alleles show no linkage relationships either among themselves or with the suppressor S.

Super-suppressor S has been shown to be closely linked (about 5 stranes) to one of the centromeres other than those of linkage groups I to XII. This establishes a new thirteenth linkage group.

The possible mechanism of action of the super-suppressor is discussed.

Type
Research Article
Information
Genetics Research , Volume 8 , Issue 1 , August 1966 , pp. 1 - 7
Copyright
Copyright © Cambridge University Press 1966

References

REFERENCES

Benzer, S. & Champe, S. P. (1961). Ambivalent rII mutations of phage T4. Proc. natn. Acad. Sci. U.S.A. 47, 1025–1038.CrossRefGoogle Scholar
Benzer, S. & Champe, S. P. (1962). A change from nonsense to sense in the genetic code. Proc. natn. Acad. Sci. U.S.A. 48, 1114–1121.CrossRefGoogle ScholarPubMed
Bridges, C. B. (1932). The suppressors of purple. Z indukt. Abstamm.-u. VererbLehre, 60, 207–218.Google Scholar
Campbell, A. (1961). Sensitive mutants of bacteriophage μ. Virology, 14, 22–32.CrossRefGoogle Scholar
Desborough, S. & Lindegren, G. (1959). Chromosome mapping of linkage data from Saccharomyces by tetrad analysis. Genetica, 30, 346–383.CrossRefGoogle ScholarPubMed
Garen, S. & Siddiqi, O. (1962). Suppression of mutants in the alkaline phosphatase structural cistron of E. coli. Proc. natn. Acad. Sci. U.S.A. 48, 1121–1127.CrossRefGoogle Scholar
Hawthorne, D. C. & Mortimer, R. K. (1960). Chromosome mapping in Saccharomyces: Centromere-linked genes. Genetics, 45, 1085–1110.CrossRefGoogle ScholarPubMed
Hawthorne, D. C. & Mortimer, R. K. (1963). Super suppressor in yeast. Genetics, 48, 617–620.CrossRefGoogle ScholarPubMed
Hwang, Y. L., Lindegren, G. & Lindegren, C. C. (1963). Mapping the eleventh centromere in Saccharomyces. Can. J. Genet. Cytol. 5, 290–298.CrossRefGoogle ScholarPubMed
Hwang, Y. L., Lindegren, G. & Lindegren, C. C. (1964). The twelfth chromosome of Saccharomyces. Can. J. Genet. Cytol. 6, 373–380.CrossRefGoogle ScholarPubMed
Lindegren, C. C. (1962). Yeast Genetics 1962. Southern Illinois University.Google Scholar
Manney, T. R. (1964). Action of a super suppressor in yeast in relation to allelic mapping and complementation. Genetics, 50, 109–121.CrossRefGoogle ScholarPubMed
Shult, E. E. & Lindegren, C. C. (1956). Mapping methods in tetrad analysis. Genetica, 28, 165–176.CrossRefGoogle Scholar
Strauss, B. S. (1960). An Outline of Chemical Genetics, chap. I. Philadelphia: Saunders.Google Scholar
Suskind, S. R. & Kurek, L. I. (1959). On a mechanism of suppressor gene regulation of tryptophan synthetase activity in Neurospora crassa. Proc. natn. Acad. Sci. U.S.A. 45, 193–196.CrossRefGoogle ScholarPubMed
von Borstel, R. C., ed, (1963). Carbondale Yeast Genetics Conference (November 16–18, 1961). Microbial Genetics Bulletin, supplement to No. 19.Google Scholar
Wagner, R. P. & Mitchell, H. K. (1955). Genetics and Metabolism, pp. 260–266. New York: Wiley.Google Scholar