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Study of the association of resistance to two drugs in a transferable determinant in Salmonella typhimurium

Published online by Cambridge University Press:  14 April 2009

E. S. Anderson ,
Marianne V. Kelemen ,
Christine M. Jones  and
J.-S. Pitton
E. S. Anderson
Affiliation:
Enteric Reference Laboratory, Public Health Laboratory Service Colindale Avenue, London, N. W. 9
Marianne V. Kelemen
Affiliation:
Enteric Reference Laboratory, Public Health Laboratory Service Colindale Avenue, London, N. W. 9
Christine M. Jones
Affiliation:
Enteric Reference Laboratory, Public Health Laboratory Service Colindale Avenue, London, N. W. 9
J.-S. Pitton
Affiliation:
Enteric Reference Laboratory, Public Health Laboratory Service Colindale Avenue, London, N. W. 9
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A strain of S. typhimurium carrying transferable determinants, one for resistance to ampicillin (A), another for resistance to streptomycin and sulphonamides (SSu), was irradiated with ultraviolet light. A clone resulting from this treatment had lost streptomycin resistance and now carried the A determinant and a new determinant, ASu. Except for coding for ampicillin resistance, the ASu determinant was homologous with SSu. The A moiety of ASu produced ampicillin (penicillin) resistance of the same degree as the original A determinant. It was therefore concluded that irradiation had resulted in the elimination of the S gene in the SSu determinant and its replacement by an A gene to form ASu. Experiments with the ASu and SSu determinants suggest that there is normally only one copy of a resistance determinant in the host cell and only one cell site into which it can integrate.

Type
Short Papers
Information
Genetics Research , Volume 11 , Issue 1 , February 1968 , pp. 119 - 124
Copyright
Copyright © Cambridge University Press 1968

References

REFERENCES

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