Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-23T00:34:37.389Z Has data issue: false hasContentIssue false
  • English
  • Français

A structural gene (Tcp-1) within the mouse t complex is separable from effects on tail length and lethality but may be associated with effects on spermatogenesis

Published online by Cambridge University Press:  14 April 2009

Lee M. Silver
Lee M. Silver
Affiliation:
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York11724
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The Tcp-1 gene is located within the t complex and codes for a major testicular cell protein called p63/6.9. All wild-type chromosomes carry the Tcp-1b allele which codes for a basic form of this protein, while all complete t haplotypes carry the Tcp-1a allele which codes for an acidic form of this protein. It is not clear whether the Tcp-1 gene is associated with phenotypic effects of t haplotypes on embryogenesis and/or spermatogenesis, since the genetic basis for these effects is extremely complex. The elegant analysis of Lyon & Mason (1977) has allowed the identification and separation of a family of genetic factors which interact to produce the observed phenotypes associated with various combinations of t haplotypes. The data summarized in this report indicate that the Tcp-1a locus is separable from all of the identified t haplotype factors except for one; a complete correlation has been obtained between Tcp-1a and a proximal t haplotype factor which is involved in effects on transmission ratio distortion. Two other novel points emerge from this analysis. First, it appears that the tail interaction factor and the proximal sperm factors represent distinct genetic loci. Second, the accumulated data lead to the proposal that the TOrl chromosome carries a short segment of t haplotype chromatin containing Tcp-1a and proximal sperm factors involved in transmission ratio distortion and sterility.

Type
Research Article
Information
Genetics Research , Volume 38 , Issue 2 , October 1981 , pp. 115 - 123
Copyright
Copyright © Cambridge University Press 1981

References

REFERENCES

Alton, A., Silver, L. M., Artzt, K. & Bennett, D. (1980). Genetic relationship of trans interacting factors at the T/t complex; A molecular analysis. Nature 288, 368–370.CrossRefGoogle Scholar
Babiarz, B. (1980). Mouse, News Letter 62, 75.Google Scholar
Bechtol, K. B. & Lyon, M. F. (1978). H-2 typing of mutants of the t6 haplotype in the mouse. Immunogenetics 6, 571–583.CrossRefGoogle Scholar
Bennett, D. (1975). The T-locus of the mouse. Cell 6, 441–454.Google Scholar
Bennett, D. (1978). Mouse News Letter 59, 60–61.Google Scholar
Bennett, D. & Dunn, L. C. (1971). Transmission ratio distorting genes on chromosome 9 and their interaction. In Proceedings of the Symposium on the Immunogenetics of the H-2 System (ed. Karger, S.), pp. 90–103. Basel: Liblice-Praque.Google Scholar
Boitani, C., Geremia, R., Rossi, R. & Monesi, V. (1980). Electrophoretic patterns of polypeptide synthesis in spermatocytes and spermatids of the mouse. Cellular Differentiation 9, 41–49.Google Scholar
Carter, T. C. & Phillips, R. J. S. (1950). Three recurrences of mutants in the house mouse. Journal of Heredity 41, 252.Google Scholar
Danska, J. S. & Silver, L. M. (1980). Cell-free translation of a T/t complex cell surface associated gene product. Cell 22, 901–904.CrossRefGoogle Scholar
Erickson, R. P., Lewis, S. E. & Slusser, K. S. (1978). Deletion mapping of the t complex of chromosome 17 of the mouse. Nature 274, 163–164.Google Scholar
Gluecksohn-Schoenheimer, S., Segal, R. & Fitch, X. (1950). Embryological tests of genetic male sterility in the house mouse. Journal of Experimental Zoology 113, 621–631.CrossRefGoogle Scholar
Gluecksohn-Waelsch, S. & Erickson, R. P. (1970). The T-locus of the mouse: implications for mechanisms of development. Current Topics in Developmental Biology 5, 281–316.CrossRefGoogle ScholarPubMed
Hammerberg, C. (1981). The influence of TOrl upon male fertility in t-bearing mice. Genetical Research. (In the Press.)CrossRefGoogle Scholar
Klein, J. & Hammerberg, C. (1977). The Control of Differentiation by the T Complex. Immunological Reviews 33, 70–104.CrossRefGoogle ScholarPubMed
Lyon, M. F. (1960). Effect of X-rays on the mutation of t-alleles in the mouse. Heredity 14, 247–252.Google Scholar
Lyon, M. F., Evans, E. P., Jarvis, S. E. & Sayers, I. (1979). t-haplotypes of the mouse may involve a change in intercalary DNA. Nature 279, 38–42.CrossRefGoogle ScholarPubMed
Lyon, M. F. & Mason, I. (1977). Information on the nature of t-haplotypes from the interaction of mutant haplotypes in male fertility and segregation ratio. Genetical Research, 29, 255–266.Google Scholar
Lyon, M. F. & Jarvis, S. E. (1980). Mouse News Letter 62, 49.Google Scholar
Lyon, M. F. & Meredith, R. (1964 a). The nature oft alleles in the mouse. I. Genetic analysis of a series of mutants derived from a lethal allele. Heredity 19, 301–312.Google Scholar
Lyon, M. F. & Meredith, R. (1964 b). The nature of t alleles in the mouse. II. Genetic analysis of an ususual mutant allele and its derivatives. Heredity 19, 313–325.CrossRefGoogle Scholar
Lyon, M. F. & Meredith, R. (1964 c). The nature of t alleles. III. Short tests of some further mutant alleles. Heredity 19, 327–330.Google Scholar
Moutier, R. (1973). Mouse News Letter 48, 38.Google Scholar
O'Farrell, P. H. & O'Farrell, P. Z. (1978). Two-dimensional polyacrylamide gel electrophoresis fractionation. Methods in Cell Biology 16, 407–420.CrossRefGoogle Scholar
Sherman, M. I. & Wudl, L. R. (1977). T-complex mutations and their effects. In Concepts in Mammalian Embryogenesis (ed. Sherman, M.), pp. 136–234. Cambridge: MIT Press.Google Scholar
Silver, L. M. & Artzt, K. (1981). Recombination suppression of mouse t-haplotypes is due to chromatin mismatching. Nature 290, 68–70.Google Scholar
Silver, L. M., Artzt, K. & Bennett, D. (1979). A major testicular cell protein specified by a mouse T/t complex gene. Cell 17, 275–284.Google Scholar
Silver, L. M., White, M. & Artzt, K. (1980). Evidence for unequal crossing over within the mouse T/t complex. Proceedings of the National Academy of Sciences 77, 6077–6080.CrossRefGoogle ScholarPubMed