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Some sampling properties of selectively neutral alleles

Effects of variability of mutation rates

Published online by Cambridge University Press:  14 April 2009

Ranajit Chakraborty  and
Paul A. Fuerst
Ranajit Chakraborty
Affiliation:
Center for Demographic and Population Genetics, University of Texas Health Science Center, Houston, Texas
Paul A. Fuerst
Affiliation:
Center for Demographic and Population Genetics, University of Texas Health Science Center, Houston, Texas
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Some sampling properties related with the mean and variance of the number of alleles and single locus heterozygosity are derived to study the effect of variations in mutation rate of selectively neutral alleles. The correlation between single locus heterozygosity and the number of alleles is also derived. Monte Carlo simulation is conducted to examine the effect of stepwise mutations. The relevance of these results in estimating the population parameter, 4Neν, is discussed in connexion with neutralist-selectionist controversy over the maintenance of genetic variability in natural populations.

Type
Research Article
Information
Genetics Research , Volume 34 , Issue 3 , December 1979 , pp. 253 - 267
Copyright
Copyright © Cambridge University Press 1979

References

REFERENCES

Chakraborty, R. (1977). Simulation results with stepwise mutation model and their interpretations. Journal of Molecular Evolution 9, 313–322.CrossRefGoogle ScholarPubMed
Chakraborty, R., Fuerst, P. A. & Nei, M. (1978). Statistical studies on protein polymorphism in natural populations. II. Gene differentiation between populations. Genetics 88, 367–390.CrossRefGoogle ScholarPubMed
Chakraborty, R., Fuerst, P. A. & Nei, M. (1980). Statistical studies on protein polymorphism in natural populations. III. Distribution of allele frequencies within populations. Genetics, (in the Press).Google Scholar
Darnall, D. W. & Klotz, I. M. (1975). Subunit constitution of proteins: A table. Archives of Biochemistry and Biophysics 166, 651–682.CrossRefGoogle ScholarPubMed
Dayhoff, M. O. (1976). Atlas of Protein Sequences and Structure, vol. 5, Suppl. 2. National Biomedical Research Foundation, Washington.Google Scholar
Eanes, W. F. & Koehn, R. K. (1978). The relationship between subunit size and the number of rare eleetrophoretio alleles in human enzymes. Biochemical Genetics 16, 971–985.CrossRefGoogle ScholarPubMed
Ewens, W. J. (1972). The sampling theory of selectively neutral alleles. Theoretical Population Biology 3, 87–112.CrossRefGoogle ScholarPubMed
Fuerst, P. A., Chakraborty, R. & Nei, M. (1977). Statistical studies on protein polymorphism in natural populations. I. Distribution of single locus heterozygosity. Genetics 86, 455–483.CrossRefGoogle ScholarPubMed
Harris, H., Hopkinson, D. A. & Edwards, Y. H. (1977). Polymorphism and the subunit structure of enzymes: A contribution to the neutralist-selectionist controversy. Proceedings of the National Academy of Sciences, U.S.A. 74, 698–701.CrossRefGoogle Scholar
Harris, H., Hopkinson, D. A. & Robson, E. B. (1974). The incidence of rare alleles determining electrophoretic variants: Data on 43 enzyme loci in man. Annals of Human Genetics, London 37, 237–253.CrossRefGoogle ScholarPubMed
Kimura, M. & Crow, J. F. (1964). The number of alleles that can be maintained in a finite population. Genetics 49, 725–738.CrossRefGoogle Scholar
Kimura, M. & Ohta, T. (1971). Theoretical Aspects of Population Genetics. Princeton University Press.Google ScholarPubMed
Koehn, R. K. & Eanes, W. F. (1977). Subunit size and genetic variation of enzymes in natural populations of Drosophila. Theoretical Population Biology 11, 330–341.CrossRefGoogle ScholarPubMed
Koehn, R. K. & Eanes, W. F. (1978). Molecular structure and protein variation within and among populations. Evolutionary Biology 11, 39–100.Google Scholar
Li, W.-H. (1979). Maintenance of genetic variability under the pressure of neutral and deleterious mutations in a finite population. Genetics (in the Press).CrossRefGoogle Scholar
Li, W.-H. & Nei, M. (1975). Drift variances of heterozygosity and genetic distance in transient states. Genetical Research 25, 229–248.CrossRefGoogle ScholarPubMed
Neel, J. V., Ueda, N., Satoh, C., Ferrell, R. E., Tanis, R. J. & Hamilton, H. B. (1978). The frequency in Japanese of genetic variants of 22 proteins. V. Summary and comparison with data on Caucasians from the British Isles. Annals of Human Genetics, London.Google Scholar
Nei, M., Chakraborty, R. & Fuerst, P. A. (1976). Infinite allele model with varying mutation rate. Proceedings of the National Academy of Sciences, U.S.A. 73, 4164–4168.CrossRefGoogle ScholarPubMed
Nei, M., Fuerst, P. A. & Chakraborty, R. (1978). Subunit molecular weight and genetic variability of proteins in natural populations. Proceedings of the National Academy of Sciences, U.S.A. 75, 3359–3362.CrossRefGoogle ScholarPubMed
Nei, M. & Roychoudhury, A. K. (1974). Sampling variances of heterozygosity and genetic distance. Genetics 76, 379–390.CrossRefGoogle ScholarPubMed
Ohta, T. & Kimura, M. (1975). Distribution of allelic frequencies in a finite population under stepwise production of neutral alleles. Proceedings of the National Academy of Sciences, U.S.A. 72, 2761–2764.Google Scholar
Stewart, F. M. (1977). Computer algorithm for obtaining a random set of allele frequencies for a locus in an equilibrium population. Genetics 86, 482–483.Google Scholar
Watterson, G. A. (1977). Heterosis or neutrality? Genetics 85, 789–814.CrossRefGoogle ScholarPubMed
Wilson, A. C., Carlson, S. S. & White, T. J. (1977). Biochemical evolution. Annual Review of Biochemistry 46, 573–639.CrossRefGoogle ScholarPubMed
Wright, S. (1949). Genetics of populations. Encyclopedia Britannica, 14th ed. 10, 111–112.Google Scholar