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Some sampling properties of selectively neutral alleles

Effects of variability of mutation rates

Published online by Cambridge University Press:  14 April 2009

Ranajit Chakraborty  and
Paul A. Fuerst
Ranajit Chakraborty
Affiliation:
Center for Demographic and Population Genetics, University of Texas Health Science Center, Houston, Texas
Paul A. Fuerst
Affiliation:
Center for Demographic and Population Genetics, University of Texas Health Science Center, Houston, Texas
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Some sampling properties related with the mean and variance of the number of alleles and single locus heterozygosity are derived to study the effect of variations in mutation rate of selectively neutral alleles. The correlation between single locus heterozygosity and the number of alleles is also derived. Monte Carlo simulation is conducted to examine the effect of stepwise mutations. The relevance of these results in estimating the population parameter, 4Neν, is discussed in connexion with neutralist-selectionist controversy over the maintenance of genetic variability in natural populations.

Type
Research Article
Information
Genetics Research , Volume 34 , Issue 3 , December 1979 , pp. 253 - 267
Copyright
Copyright © Cambridge University Press 1979

References

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