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Small, inherited differences in blood glucose levels in mice

Published online by Cambridge University Press:  14 April 2009

Deborah Charlesworth
Deborah Charlesworth
Affiliation:
Department of Genetics, Milton Road, Cambridge.
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Blood glucose levels of mice from five strains were measured. The results showed that each strain was different from the others for genes affecting blood glucose level, although the strain differences were small.

Within strains, the chief sources of variation were sex differences, differences between mice from different litters of the same mother, and between mice assayed in different months. Repeatability of measurements on individual mice was low. Genetic analysis, even by biometrical techniques, was not possible because the small genetic effects were obscured by variation due to other causes.

Type
Research Article
Information
Genetics Research , Volume 14 , Issue 1 , August 1969 , pp. 1 - 7
Copyright
Copyright © Cambridge University Press 1969

References

REFERENCES

Bergmeyer, H.-U. & Bernt, E. (1963). In Methods of Enzymic Analysis (ed. H-U., Berg-meyer). Verlag Chemie. G.M.B.H. Weinheim/Bergstr.Google Scholar
Carpenter, K. J. & Mayer, J. (1958). Physiologic observations on yellow obesity in the mouse. Am. J. Physiol. 193, 499–504.CrossRefGoogle ScholarPubMed
Crofford, O. B. & Davis, C. K. Jr. (1965). Growth characteristics glucose tolerance and insulin sensitivity of New Zealand Obese mice. Metabolism 14, 271–280.CrossRefGoogle ScholarPubMed
Hummel, K. P., Dickie, M. M. & Coleman, D. L. (1966). Diabetes, a new mutation in the mouse. Science, N.Y. 153, 1127–1128.CrossRefGoogle ScholarPubMed
Kempthorne, O. (1957). An Introduction to Genetic Statistics. New York: Wiley.Google Scholar
Mayer, V., Bates, M. W. & Dickie, M. M. (1951). Hereditary diabetes in genetically obese mice. Science, N.Y. 113, 746–747.CrossRefGoogle ScholarPubMed
Wright, S. (1952). Genetics of quantitative variation. In Quantitative Inheritance (ed. Reeve, E. C. R. and Waddington, C. H.). London: H.M.S.O.Google Scholar