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The size and endocrine activity of the pituitary in mice selected for large or small body-size

Published online by Cambridge University Press:  14 April 2009

R. G. Edwards
Affiliation:
Division of Experimental Biology, National Institute for Medical Research, Mill Hill, London, N.W.7
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Mice of two strains, N and C, were used in studies on body-size, pituitary size, and endocrine potency of the pituitary. Strain N had been selected for large (NL) and small (NS) body-size; strain C had also been selected for large body-size (CL) but had been crossed to an outbred strain segregating pituitary dwarfism.

Pituitary weights and body-weights were highly correlated, the regression lines being common in NL and NS mice. Female pituitaries were considerably heavier than male pituitaries in CL mice. In relation to body-weight, CL pituitaries were consistently heavier than those of NL or NS mice.

No differences were detected in the unit potency of gonadotrophins in the pituitaries of NL and NS mice as estimated by the uterine response of immature outbred mice to subcutaneous injections of pituitary tissue. The uptake of 131I into the thyroid was comparable in NL and NS mice per unit of body-weight, and the thyroid secretion rate was also similar using animals of the same body-weight. Immature mice of both lines responded by increased growth to injections of growth hormone or fresh mouse pituitary, though the response was greater in NS than in NL mice.

The primary response to selection has probably been in the size of the pituitary rather than in its unit potency. The interrelationships between body-size, body components, organ size and endocrine levels are discussed.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1962

References

REFERENCES

Amin, A., Chai, C. K. & Reineke, E. P. (1957). Differences in thyroid activity of several strains of mice and F1 hybrids. Amer. J. Physiol. 191, 3436.CrossRefGoogle ScholarPubMed
Baird, D. N., Nalbandov, A. V. & Norton, H. W. (1952). Some physiological causes of genetically different rates of growth in swine. J. anim. Sci. 11, 292300.CrossRefGoogle Scholar
Bliss, C. H. (1952). Statistics of Bioassay, p. 472. New York: Academic Press.Google Scholar
Bowman, R. H. (1961). Growth hormone activity of the anterior pituitary lobe of the male rat at various ages. Nature, Lond., 192, 967977.CrossRefGoogle ScholarPubMed
Carsner, R. L. & Rennels, E. G. (1960). Primary site of gene action in anterior pituitary dwarf mice. Science, 131, 829.CrossRefGoogle ScholarPubMed
Claringbold, P. J. & Lamond, D. R. (1957). Optimum conditions for the bioassay of gonadotrophins. J. Endocrin. 16, 8697.CrossRefGoogle Scholar
Elftman, H. & Wegelius, O. (1959). Anterior pituitary cytology of the dwarf mouse. Anat. Rec. 135, 4349.CrossRefGoogle ScholarPubMed
Emerson, J. D. & Emerson, G. M. (1960). Effect of dosage on plateauing in adult female Norway rats receiving a growth hormone containing pituitary extract. Endocrinology, 67, 170178.CrossRefGoogle ScholarPubMed
Evans, H. M. & Simpson, M. E. (1929). A sex difference in the hormone content of the anterior hypophysis of the rat. Amer. J. Physiol. 89, 375378.CrossRefGoogle Scholar
Falconer, D. S. (1953). Selection for large and small size in mice. J. Genet. 51, 470501.CrossRefGoogle Scholar
Falconer, D. S. (1960). Selection of mice on high and low planes of nutrition. Genet. Res. 1, 91113.CrossRefGoogle Scholar
Falconer, D. S. & Isaacson, J. H. (1959). Adipose, a new inherited obesity of the mouse. J. Hered. 50, 290292.CrossRefGoogle Scholar
Finney, D. J. (1952). Statistical Method in Biological Assay, p. 113. London: Griffin & Co. Ltd.Google Scholar
Foley, C. W., Heidenreich, C. J. & Lasley, J. F. (1960). Influence of the dwarf gene on insulin sensitivity. J. Hered. 51, 278283.CrossRefGoogle Scholar
Fowler, R. E. (1958). The growth and carcass composition of strains of mice selected for large and small body size. J. agric. Sci. 51, 137148.CrossRefGoogle Scholar
Fowler, R. E. (1962). The efficiency of food utilization, digestibility of foodstuffs and energy expenditure of mice selected for large or small body size. Genet. Res. 3, 5168.CrossRefGoogle Scholar
Fowler, R. E. & Edwards, R. G. (1960). The fertility of mice selected for large or small body size. Genet. Res. 1, 393407.CrossRefGoogle Scholar
Fowler, R. E. & Edwards, R. G. (1961). Midget, a new dwarfing gene in the house mouse dependent on a genetic background of small body size for its expression. Genet. Res. 2, 272282.CrossRefGoogle Scholar
Francis, T. (1944). Studies on hereditary dwarfism in mice. Acta path. microbiol. scand. 21, 928956.CrossRefGoogle Scholar
Greep, R. O. & Jones, I. C. (1950). Steroid control of pituitary function. Recent Progr. Hormone Res. 5, 197254.Google Scholar
Grosvenor, C. E. & Turner, C. W. (1960). Pituitary lactogenic hormone concentration during pregnancy in the rat. Endocrinology, 66, 9699.CrossRefGoogle ScholarPubMed
Knobil, E. & Greep, R. O. (1959). The physiology of growth hormone with particular reference to its action in the rhesus monkey and the ‘species specificity’ problem. Recent Progr. Hormone Res. 15, 197254.Google Scholar
Ladman, A. J. & Runner, M. N. (1953). Demonstration of storage and release of gonadotrophin by the anterior pituitary of the mouse during gestation. Endocrinology, 53, 367379.CrossRefGoogle ScholarPubMed
Ladman, A. J. & Runner, M. N. (1959). Correlation of maternal pituitary weight with the number of uterine implantation sites in pregnant mice. Endocrinology, 65, 580585.CrossRefGoogle ScholarPubMed
Lane, P. W. (1959). The pituitary-gonad response of genetically obese mice in parabiosis with thin and obese siblings. Endocrinology, 65, 863868.CrossRefGoogle ScholarPubMed
Li, C. H., Papkoff, H. & Jordan, C. W. (1959). Differences in biological behaviour between primate and beef or whale pituitary growth hormone. Proc. Soc. exp. Biol., N.Y., 100, 4445.CrossRefGoogle ScholarPubMed
Marlowe, T. J. (1960). A comparison of the growth hormone content of the pituitary glands from dwarf and normal beef calves. J. Anim. Sci. 19, 810819.CrossRefGoogle Scholar
Raben, M. S. (1959). Human growth hormone. Recent Progr. Hormone Res. 15, 71105.Google Scholar
Reichlin, S. (1960). Growth and the hypothalamus. Endocrinology, 67, 763773.CrossRefGoogle Scholar
Robinson, P. F. & Wilber, C. G. (1961). Organ:body weight relationships in the hamster. Anat. Rec. 141, 3133.CrossRefGoogle ScholarPubMed
Silverstein, E., Sokoloff, L., Mikelsen, O. & Jay, G. E. (1960). Thyroid function in various strains of mice: T/S ratios, PBI and thyroid weight. Amer. J. Physiol. 199, 203208.CrossRefGoogle Scholar
Smith, P. E. & MacDowell, E. C. (1930). An hereditary anterior pituitary deficiency in the mouse. Anat. Rec. 46, 249258.CrossRefGoogle Scholar
Smith, P. E. & MacDowell, E. C. (1931). The differential effect of hereditary mouse dwarfism on the anterior pituitary hormone. Anat. Rec. 50, 8593.CrossRefGoogle Scholar
Smithberg, M. & Runner, M. N. (1957). Pregnancy induced in genetically sterile mice. J. Hered. 48, 97100.CrossRefGoogle Scholar
Solomon, J. & Greep, R. O. (1958). Relationship between pituitary growth hormone content and age in rats. Proc. Soc. exp. Biol., N.Y., 99, 725727.CrossRefGoogle ScholarPubMed
Wada, H., Berswordt-Wallrabe, R. & Turner, C. W. (1959). Thyroxine secretion rate of mice. Proc. Soc. exp. Biol., N.Y., 102, 608612.CrossRefGoogle Scholar
Wegelius, O. (1959). The dwarf mouse—an animal with secondary myxedema. Proc. Soc. exp. Biol., N.Y., 101, 225227.CrossRefGoogle Scholar
Widdowson, E. M. & McCance, R. A. (1960). Some effects of accelerating growth. I. General somatic development. Proc. roy. Soc. B, 152, 188206.Google ScholarPubMed
Witschi, E. & Riley, G. M. (1940). Quantitative studies on the hormones of the human pituitary. Endocrinology, 26, 565576.CrossRefGoogle Scholar
Wolff, J. (1951). Some factors that influence the release of iodine from the thyroid gland. Endocrinology, 48, 284297.CrossRefGoogle ScholarPubMed
Wykes, A. A., Christian, J. E. & Andrews, F. N. (1958). Radioiodine concentration and thyroid weight in normal, obese and dwarf strains of mice. Endocrinology, 62, 535538.Google ScholarPubMed