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The role of growth hormone in lines of mice divergently selected on body weight

Published online by Cambridge University Press:  14 April 2009

Ian M. Hastings ,
Lorna H. Bootland  and
William G. Hill
Ian M. Hastings*
Affiliation:
Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, Scotland
Lorna H. Bootland
Affiliation:
Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, Scotland
William G. Hill
Affiliation:
Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, Scotland
*
*Corresponding author.
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An understanding of the physiological and genetic changes which determine the response to selection is critical for both evolutionary theory and to assess the application of new molecular techniques to commercial animal breeding. We investigated an aspect of physiology, growth hormone (GH) metabolism, which might a priori have been expected to play a large part in the response of mouse lines selected for high or low body weight. Disruption of endogenous GH or addition of exogenous GH had similar proportionate effects on body weight in both lines of mice (although differences in body composition arose) suggesting that neither the production of GH nor receptor sensitivity to GH had been altered as a result of selection. This supports a ‘pleiotropic model’ of the response to selection: that many genes with diverse metabolic roles all contribute to the divergent phenotype. This result has significant commercial implications as it suggests that artificial selection, transgenic technology and environmental manipulation may be synergistic rather than antagonistic strategies.

Type
Research Article
Information
Genetics Research , Volume 61 , Issue 2 , April 1993 , pp. 101 - 106
Copyright
Copyright © Cambridge University Press 1993

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