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Relative growth of the skull and postcranium in giant transgenic mice

Published online by Cambridge University Press:  14 April 2009

Brian T. Shea ,
Robert E. Hammer ,
Ralph L. Brinster  and
Matthew R. Ravosa
Brian T. Shea*
Affiliation:
Departments of Cell, Molecular and Structural Biology and Anthropology, Northwestern University, 303 East Chicago Avenue, Chicago IL 60611, USA
Robert E. Hammer
Affiliation:
Laboratory of Reproductive Physiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia PA 19104, USA
Ralph L. Brinster
Affiliation:
Laboratory of Reproductive Physiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia PA 19104, USA
Matthew R. Ravosa
Affiliation:
Departments of Cell, Molecular and Structural Biology and Anthropology, Northwestern University, 303 East Chicago Avenue, Chicago IL 60611, USA
*
† Corresponding author.
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Cross-sectional allometric growth patterns of the cranial and postcranial skeleton were compared between giant transgenic (MT-rGH) mice and their normal littermate controls. Body weights, external body dimensions, and a series of cranial and postcranial linear dimensions of the skeleton were determined for samples of known age. Comparative bivariate and multivariate allometric analyses were completed in order to determine whether (1) the larger transgenic mice differed significantly from the normal controls in aspects of body and skeletal proportions, and (2) any such proportion differences resulted from general allometric effects of overall weight or skeletal size increase. Results demonstrate that the transgenic mice do exhibit significantly different body and skeletal proportions than normal control adults. Allometric comparisons of the skeletal dimensions relative to body weight reveal similar coefficients of growth allometry but several differences in y-intercept values in the transgenic vs. control groups. The comparisons among the skeletal dimensions of the skull and postcranium generally reveal the sharing and differential extension of common growth allometries in the two groups. Thus, the elevated levels of growth hormone (GH) and insulin-like growth factor I (IGF-I) in the transgenic mice appear to result in increased overall growth for the various skeletal elements, but in the relative proportions determined by intrinsic growth controls within that system.

Type
Research Article
Information
Genetics Research , Volume 56 , Issue 1 , August 1990 , pp. 21 - 34
Copyright
Copyright © Cambridge University Press 1990

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