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Recombination during blocked chromosome replication in temperature-sensitive strains of Ustilago maydis

Published online by Cambridge University Press:  14 April 2009

P. Unrau  and
R. Holliday
P. Unrau
Affiliation:
National Institute for Medical Research, Mill Hill, London, N. W. 7
R. Holliday
Affiliation:
National Institute for Medical Research, Mill Hill, London, N. W. 7
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Summary

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tsd1–1 strains of Ustilago maydis are blocked in DNA synthesis under restrictive conditions. On recovery from the block, both intergenic and allelic recombination are enhanced, and aneuploids are generated. UV is synergistic in the induction of recombination. Direct assays of allelic recombination have shown that gene conversion occurs during the block in DNA synthesis.

Type
Research Article
Information
Genetics Research , Volume 19 , Issue 2 , April 1972 , pp. 145 - 155
Copyright
Copyright © Cambridge University Press 1972

References

REFERENCES

Bernstein, H. (1967). The effect on recombination of mutational defects in the DNA polymerase and deoxycytidylate hydroxymethylase of phage T4D. Genetics 56, 755–769.CrossRefGoogle ScholarPubMed
Chiang, K. S. & Sueoka, N. (1967). Replication of chromosomal and cytoplasmic DNA during mitosis and meiosis in the eucaryote Chlamydomonas reinhardi. Journal of Cell Physiology 70 (Suppl.), 89–112.CrossRefGoogle ScholarPubMed
Esposito, R. E. & Holliday, R. (1964). The effect of 5-fluorodeoxyuridine on genetic replication and mitotic crossing-over in synchronized cultures of Ustilago maydis. Genetics, Princeton 50, 1009–1017.CrossRefGoogle ScholarPubMed
Freifelder, D. (1969). Single strand breaks in bacterial DNA associated with thymine starvation. Journal of Molecular Biology 45, 1–7.CrossRefGoogle ScholarPubMed
Gallant, J. & Spottswood, T. (1965). The recombinagenie effect of thymidylate starvation in Escherichia coli merodiploids. Genetics, Princeton 52, 107–118.CrossRefGoogle ScholarPubMed
Guerola, N., Ingraham, J. L. & Cerdá-Olmedo, E. (1971). Induction of closely linked multiple mutations by nitrosoguanidine. Nature New Biol. 230, 122–125.CrossRefGoogle ScholarPubMed
Hartwell, L. H. (1971). Genetic control of the cell division cycle in yeast. II. Genes controlling DNA replication and its initiation. Journal of molecular Biology 59, 183–194.CrossRefGoogle ScholarPubMed
Henderson, S. A. (1966). Time of chiasma formation in relation to the time of deoxyribo-nucleic acid synthesis. Nature 211, 1043–1047.CrossRefGoogle Scholar
Holliday, R. (1961). Induced mitotic crossing-over in Ustilago maydis. Genetical Research 2, 231–248.CrossRefGoogle Scholar
Holliday, R. (1964). The induction of mitotic recombination by mitomycin C in Ustilago and Saccharomyces. Genetics, Princeton 50, 323–335.CrossRefGoogle ScholarPubMed
Holliday, R. (1967). Altered recombination frequencies in radiation sensitive strains of Ustilago. Mutation Research 4, 275–288.CrossRefGoogle Scholar
Holliday, R. (1968). Genetic recombination in fungi. In Replication and Recombination of Genetic Material, pp. 157–174. Australian Academy of Science.Google Scholar
Holliday, R. (1971). Biochemical measure of the time and frequency of radiation-induced allelic recombination in Ustilago. Nature New Biol. 232, 233–236.CrossRefGoogle ScholarPubMed
Holliday, R. & Resnick, M. (1970). Allelic recombination and DNA degradation in Ustilago. Abstract in Heredity 25, 494.Google Scholar
Howard-Flanders, P. (1968). DNA repair. Annual Revue of Biochemistry 37, 175–200.CrossRefGoogle ScholarPubMed
Joshi, G. P. & Siddiqi, O. (1968). Enzyme synthesis following conjugation and recombination in Escherichia coli. Journal of molecular Biology 32, 201–210.CrossRefGoogle ScholarPubMed
Peacock, W. J. (1970). Replication, recombination and chiasmata in Goniaea australasiae (Orthoptera: Acrididae). Genetics, Princeton 65, 595–617.CrossRefGoogle ScholarPubMed
Pontecorvo, G. (1958). Trends in Genetic Analysis. New York: Columbia University Press.Google Scholar
Rossen, J. M. & Westergaard, M. (1966). Studies on the mechanisms of crossing-over. II. Meiosis and the time of meiotic chromosome replication in the ascomycete Neotiella rutilans (Fr.) Dennis. Compte rendu des travaux du Laboratoire de Carlsberg 35, 233–260.Google Scholar
Taylor, J. H. (1965). Distribution of tritium-labelled DNA among chromosomes during meiosis. I. Spermiogenesis in the grasshopper. Journal of Cell Biology 25, 57–67.Google Scholar
Unrau, P. (1968). Temperature-sensitive mutants of Ustilago maydis and their effects on replication and recombination. Ph.D. thesis, University of London.Google Scholar
Unrau, P. & Holliday, R. (1970). A search for temperature-sensitive mutants of Ustilago maydis blocked in DNA synthesis. Genetical Research 15, 157–169.CrossRefGoogle ScholarPubMed
Wildenberg, J. (1970). The relation of mitotic recombination to DNA replication in yeast pedigrees. Genetics 66, 291–304.CrossRefGoogle ScholarPubMed
Witkin, E. M. (1969). Ultraviolet-induced mutation and DNA repair. Annual Revue Microbiology 23, 487–514.CrossRefGoogle ScholarPubMed
Zimmermann, F. K., Schwaier, R. & Von Laer, U. (1966). Mitotic recombination induced in Saccharomyces cerevisiae with nitrous acid, diethylsulphate and carcinogenic, alkylating nitrosamides. Zeitschrift für Vererbungslehre 98, 230–246.Google Scholar