Hostname: page-component-cd9895bd7-dzt6s Total loading time: 0 Render date: 2024-12-25T06:30:07.915Z Has data issue: false hasContentIssue false
  • English
  • Français

Recessive mutation in a standard recombinant-inbred line of mice affects seminal vesicle shape

Published online by Cambridge University Press:  14 April 2009

N. M. Shukri ,
F. Grew  and
J. G. M. Shire
N. M. Shukri
Affiliation:
Department of Biology, University of Essex, Colchester CO4 3SQ
F. Grew
Affiliation:
Department of Biology, University of Essex, Colchester CO4 3SQ
J. G. M. Shire
Affiliation:
Department of Biology, University of Essex, Colchester CO4 3SQ
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A recessive autosomal mutation has been found in the CXBI/ByEss recombinant-inbred line but in neither of the parental strains, C57BL/6ByEss and BALB/cByEss. Its presence in the CXBI/ByJax and CXBI/ByLac sublines suggests an origin early in inbreeding. The locus, seminal vesicle shape (svs), appears to be linked to the albino locus on chromosome 7. The homozygote has seminal vesicles with a smooth tubular external appearance. In segregating crosses homozygotes had slightly lighter seminal vesicles but the weights of other androgen target organs were not reduced. Exogenous testosterone increased the size of the seminal vesicles but did not alter their shape. The mutation did not affect the pattern of proteins on SDS–acrylamide gel electrophoresis, which did differ between the parental strains. The locus affecting a 27000 Da protein has provisionally been assigned the symbol svp-4.

Type
Research Article
Information
Genetics Research , Volume 52 , Issue 1 , August 1988 , pp. 27 - 32
Copyright
Copyright © Cambridge University Press 1988

References

Bailey, D. W. (1971). Recombinant strains: An aid to finding identity, linkage and function of histocompati-bility and other genes. Transplantation 11, 325–327.Google Scholar
Bailey, D. W. & Hoste, J. (1971). A gene governing the female immune response to the male antigen in mice. Transplantation 11, 404–407.CrossRefGoogle Scholar
Bartke, A. (1974). Increased sensitivity of seminal vesicles to testosterone in a mouse strain with low plasma testosterone levels. Journal of Endocrinology 60, 145–148.Google Scholar
Greenblatt, H. C., Diggs, C. L. & Rosenstreich, D. L. (1984). Trypanosoma rhodesiense: analysis of the genetic control of resistance amongst mice. Infection and Immunity 44, 107–111.CrossRefGoogle Scholar
Hooker, C. W. & Strong, L. C. (1941). Duplication of the seminal vesicles in mice of the C strain. Anatomical Record 81, 333–349.Google Scholar
Hummel, K. P., Richardson, F. L. & Fekete, E. (1966). Anatomy, In Biology of the Laboratory Mouse, 2nd edn (ed. Green, E. L.), pp. 247–307. New York: McGraw-Hill.Google Scholar
Janat, F. M. & Shire, J. G. M. (1987). The adrenal x-zone of mice: genetic analysis of its development with recom-binant-inbred strains. Experimental Biology 46, 217–222.Google ScholarPubMed
Kistler, M. K., Taylor, R. E., Kandala, J. C. & Kistler, W. S. (1981). Isolation of recombinant plasmids containing structural gene sequences for rat seminal vesicle secretory proteins IV and V. Biochemical and Biophysical Research Communications 99, 1161–1166.CrossRefGoogle ScholarPubMed
McDonald, C., Williams, L., McTurk, P., Fuller, F., McIntosh, E. & Higgins, S. (1983). Isolation and characterisation of genes for androgen-responsive secretory proteins of rat seminal vesicles. Nucleic Acids Research 11, 917–930.CrossRefGoogle ScholarPubMed
Maffei, A., Paonessa, P., Abrescia, P., Metafora, S. & Guardiola, J. (1984). Polymorphism of rat seminal vesicle secretory proteins: Characterization of svp-1 and svp-2 and their identification with major secretory proteins IV and V. Biochemical Genetics 22, 567–576.CrossRefGoogle ScholarPubMed
Moutier, R. & Bertrand, M. F. (1983). Svp-3, a third polymorphic locus for mouse seminal vesicle protein. Biochemical Genetics 21, 797–800.Google Scholar
Moutier, R., Toyama, K. & Charrier, M. F. (1971). Contrôle génétique des protéines de la sécrétion des glandes séminales chez la souris et le rat Expérimentation animate 4, 7–18.Google Scholar
O'Farrell, M. K. & Dixon, C. (1986). Biosynthesis of nuclear proteins after stimulation of quiescent Swiss mouse 3T3 cells. Journal of Cell Science 82, 173–186.CrossRefGoogle ScholarPubMed
Peets, J. M. & Pomeranz, B. (1978). CXBK mice deficient in opiate receptors show poor electroacupuncture analgesia. Nature 273, 675–676.Google Scholar
Platz, R. D. & Wolfe, H. G. (1969). Mouse seminal vesicle proteins. The inheritance of electrophoretic variants. Journal of Heredity 60, 187–192.Google Scholar
Risser, R. & Kaehler, D. (1985). Susceptibility of Abelson or Moloney murine leukemia viruses. In The BALB/c mouse: Genetics and Immunology (ed. Potter, M.), pp. 162–168. Berlin: Springer-Verlag.Google Scholar
Shire, J. G. M. (1984). Studies on the inheritance of vaginal septa in mice, a trait with low penetrance. Journal of Reproduction and Fertility 70, 333–339.Google Scholar
Shire, J. G. M. & Whitten, W. K. (1980). Genetic variation in the timing of first cleavage in mice: effect of maternal genotype. Biology of Reproduction 23, 369–376.Google Scholar
Shukri, N. M. & Shire, J. G. M. (1986). Association of H-2 with variation in testicular development in CXB mice. Genetical Research 47, 222.Google Scholar
Swank, R. T. & Bailey, D. W. (1973). Recombinant inbred lines: value in the genetic analysis of biochemical variants. Science 181, 1249–1251.CrossRefGoogle ScholarPubMed
Taylor, B. A. (1978). Recombinant inbred strains: use in gene mapping. In Origins of Inbred Mice (ed. Morse, H. C.), pp. 423–438. New York: Academic Press.Google Scholar
Taylor, B. A. (1982). Linkage of Svp-2. Mouse Newsletter 67, 22.Google Scholar