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The production of translocations in spermatogonial cells of Drosophila by chloroethyl methanesulphonate (CB 1506)

Published online by Cambridge University Press:  14 April 2009

W. A. F. Watson
W. A. F. Watson
Affiliation:
Institute of Animal Genetics, Edinburgh 9
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Adult Drosophila males were injected with chloroethyl methanesulphonate and late progeny, tracing back to treated spermatogonia, were examined for sex-linked lethals and for translocations involving the X, Y, second and third chromosomes. A dose yielding about 20% sex-linked lethals produced 11 translocations in about 3500 tested chromosome sets (approx. 0·3%). This result is discussed in relation to the problem of chromosome rearrangements in different germ-cell stages.

Type
Research Article
Information
Genetics Research , Volume 3 , Issue 3 , November 1962 , pp. 467 - 471
Copyright
Copyright © Cambridge University Press 1962

References

REFERENCES

Alexander, Mary L. (1960). Radiosensitivity at specific autosomal loci in mature sperm and spermatogonial cells of Drosophila melanogaster. Genetics, 45, 1019–1022.CrossRefGoogle ScholarPubMed
Auerbach, C. (1949). Nuclear effects of chemical substances. Proc. 6th int. Congr. Cytol. 1947; Exp. Cell Res. Suppl. 1, 93–96.Google Scholar
Auerbach, C. & Sostbati, E. M. (1960). Sensitivity of the Drosophila testis to the mutagenic action of mustard gas. Z. indukt. Abstamm.- VererbLehre, 91, 237–252.Google Scholar
Bateman, A. J. & Chandley, A. C. (1959). Mutation spectrum of immature germ cells. Drosophila Inform. Serv. 33, 120.Google Scholar
Catsch, A. & Radu, Gh. (1943). Über die Abhängigkeit der röntgeninduzierten Trans-lokationsrate vom Reifezustand der bestrahlten Gameten bei Drosophila melanogaster Männchen. Naturwissenschaften, 31, 368–369.Google Scholar
Fahmy, O. G. & Fahmy, M. J. (1956). Mutagenicity of 2-chloroethyl methanesulphonate in Drosophila melanogaster. Nature, Lond., 77, 996–997.Google Scholar
Fahmy, O. G. & Fahmy, M. J. (1957). Mutagenic response to the alkylmethanesulphonates during spermatogenesis in Drosophila melanogaster. Nature, Lond., 180, 31–34.CrossRefGoogle Scholar
Fahmy, O. G. & Fahmy, M. J. (1960). Cytogenetic analysis of carcinogens and tumor inhibitors in Drosophila melanogaster. VIII. Selective mutagenic activity of S-2-chloroethylcysteine on the spermatogonial stages. Genetics, 45, 1191–1203.CrossRefGoogle ScholarPubMed
Griffen, A. G. (1958). Occurrence of chromosomal aberrations in prespermatocytic cells of irradiated male mice. Proc. nat. Acad. Sci., Wash., 44, 691–694.Google Scholar
Hertwig, P. (1940). Vererbbare Semisterilität bei Mäusen nach Röntgenbestrahlung, verursacht durch reziproke Chromosomentranslokationen. Z. indukt. Abstamm.- u. VererbLehre, 79, 1–27.Google Scholar
Muller, H. J. (1954). The nature of the genetic effects produced by radiation. Radiation Biology (ed. Hollaender, ), Vol. I, Chapter 7, Section 10.Google Scholar
Nilan, R. A. (1961). In Mutation and Plant Breeding, Publ. 891, Nat. Acad. Sci., Washington, U.S.A., p. 142.Google Scholar
Purdom, C. E. (1957). Autonomous action of lethal mutations induced in the germ cells of Drosophila melanogaster by 2-chloroethyl methanesulphonate. Nature, Lond., 180, 81–83.Google Scholar
Reddi, O. S. & Auerbach, C. (1960). Induction of translocations in spermatogonia of Drosophila by CB 1506 (2-chloroethyl methanesulphonate). Drosophila Inform. Serv. 34, 103.Google Scholar
Russell, W. L. (1954). Genetic effects of radiation on mammals. Radiation Biology (ed. Hollaender, ), Vol. I, Chapter 12.Google Scholar
Sävhagen, R. (1960). The relation between the rate of induced translocations and treated germ cell stages in males of Drosophila melanogaster. Hereditas, Lund., 46, 651–667Google Scholar
Slizynska, H. (1957). Cytological analysis of formaldehyde induced chromosomal changes in Drosophila melanogaster. Proc. roy. Soc. Edinb. B, 66, 288–304.Google Scholar
Sonbati, E. M. (1959). Studies on chemical mutagenesis with Drosophila melanogaster, with particular reference to the sensitivity of the germ cells. Ph.D. Thesis, Edinburgh.Google Scholar
Traut, H. (1960). Über die Abhängigkeit der Rate strahleninduzierter Translokationen und recessiv geschlechtsgebundener Letalfaktoren vom Stadium der Spermatogenese bei Drosophila melanogaster. Z. indukt. Abstamm.- u. VererbLehre, 91, 201–205.Google Scholar