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The positions of the centromeres in linkage groups II and IX of the mouse

Published online by Cambridge University Press:  14 April 2009

Mary F. Lyon ,
Jane M. Butler  and
Richard Kemp
Mary F. Lyon
Affiliation:
M.R.C. Radiobiological Research Unit, Harwell, Berkshire
Jane M. Butler
Affiliation:
M.R.C. Radiobiological Research Unit, Harwell, Berkshire
Richard Kemp
Affiliation:
M.R.C. Radiobiological Research Unit, Harwell, Berkshire
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In mice heterozygous for translocation T(2;?)163H, and also for linkage group II markers, the cw locus shows close linkage with the point of rearrangement (about 1−2% recombination). Since T 163 was apparently formed by fusion of two chromosomes near their centromeres, this means that the centromere must lie at the cw end of linkage group II. In homozygotes for T(2; 9)138Ca the genes T and d show significant linkage, indicating that their loci are on opposite sides of the trans-location break. Since, from previous data, the break is known to be proximal to d, it must then be distal to T and, again from previous data, the order of loci hi linkage group IX must be centromere-T-tf-T 138 break.

Type
Research Article
Information
Genetics Research , Volume 11 , Issue 2 , April 1968 , pp. 193 - 199
Copyright
Copyright © Cambridge University Press 1968

References

REFERENCES

Allen, S. L. (1955). Linkage relations of the genes histo-compatibility-2 and fused tail, brachyury and kinky-tail in the mouse, as determined by tumour transplantation. Genetics 40, 627–650.CrossRefGoogle Scholar
Evans, E. P., Lyon, M. F. & Daglish, M. (1967). A mouse translocation giving a metacentric marker chromosome. Cytogenetics 6, 105–119.CrossRefGoogle ScholarPubMed
Falconer, D. S. & Isaacson, J. H. (1966). Curly-whiskers and its linkage with tail-kinks in linkage group II of the mouse. Genet. Res. 8, 111–113.CrossRefGoogle ScholarPubMed
Fredga, K. (1964). A simple technique for demonstration of the chromosomes and mitotic stages in a mammal. Chromosomes from cornea. Hereditas 51, 268–273.CrossRefGoogle Scholar
Green, M. C. (1967). Private communication. Mouse News Lett. 36, 40.Google Scholar
Green, M. C. & Stimpfling, J. H. (1966). Private communication. Mouse News Lett. 35, 32.Google Scholar
Klein, E. (1961). Studies on the mechanism of isoantigenic variant formation in heterozygous mouse tumors. I. Behaviour of H-2 antigens D and K: quantitative absorption tests on mouse sarcomas. J. natn. Cancer Inst. 27, 1069–1093.Google Scholar
Klein, G. & Klein, E. (1958). Histocompatibility changes in tumours. J. cell. comp. Physiol. 52 (supp.1), 125–168.CrossRefGoogle Scholar
Klein, E. & Klein, G. (1964). Studies on the mechanism of isoantigenic variant formation in heterozygous mouse tumors. III. Behaviour of H-2 antigens D and K when located in the trans position. J. natn. Cancer Inst. 32, 569–578.Google Scholar
Léonard, A. & Deknudt, Gh. (1967). A new marker for chromosome studies in the mouse. Nature, Lond. 214, 504–505.CrossRefGoogle ScholarPubMed
Lyon, M. F. & Phillips, R. J. S. (1959). Crossing-over in mice heterozygous for t-alleles. Heredity, Lond. 13, 23–32.CrossRefGoogle Scholar
Shreffler, D. C. (1965). The Ss system of the mouse—a quantitative serum protein difference genetically controlled by the H-2 region. In Isoantigens and Cell Interactions. Wistar Institute Symposium Monograph, no. 3, ed. Palm, J..Google Scholar
Snell, G. D. & Stimpfling, J. H. (1967). Genetics of tissue transplantation. In Biology of the Laboratory Mouse, 2nd ed. Ed. Green, E. L.. New York: Blakiston.Google Scholar