Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-26T08:50:58.379Z Has data issue: false hasContentIssue false
  • English
  • Français

Polymorphism of t-complex genes in European wild mice

Published online by Cambridge University Press:  14 April 2009

Jan Klein ,
Peter Sipos  and
Felipe Figueroa
Jan Klein
Affiliation:
Abteilung Immungenetik, Max-Planck-Institut für Biologie, Corrensstrasse 42, D-7400 Tübingen, F.R.G.
Peter Sipos
Affiliation:
Abteilung Immungenetik, Max-Planck-Institut für Biologie, Corrensstrasse 42, D-7400 Tübingen, F.R.G.
Felipe Figueroa
Affiliation:
Abteilung Immungenetik, Max-Planck-Institut für Biologie, Corrensstrasse 42, D-7400 Tübingen, F.R.G.
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Thirty-two t haplotypes were extracted from wild mice captured in Central Europe, Spain, the Soviet Union, Israel, Egypt, the Orkneys and South and North America, and tested for lethality in the homozygous state. Twenty-two proved to be homozygous lethals, 8 semilethals and 2 viables. The lethal t haplotypes were then tested by the genetic complementation test for identity with representatives of known complementation groups and with each other. Five of the 22 haplotypes proved to carry previously identified lethality factors (tw5, tw73, and tLub-1), while the rest carried new factors. The 17 haplotypes fell into 8 new complementation groups. Two of the new groups are partially overlapping in that they seem to share some lethality factors and differ in others. These tests raise the total number of known complementation groups to 16. The distribution of the individual t haplotypes among wild mice populations seems to reflect their differentiation from a common ancestor haplotype.

Type
Research Article
Information
Genetics Research , Volume 44 , Issue 1 , August 1984 , pp. 39 - 46
Copyright
Copyright © Cambridge University Press 1984

References

REFERENCES

Adolph, S. & Klein, J. (1983). Genetic variation of wild mouse populations in Southern Germany. I. Cytogenetic study. Genetical Research 41, 117–134.CrossRefGoogle ScholarPubMed
Artzt, K., Babiarz, B. & Bennett, D. (1979). A t-haplotype (tw75) overlapping two complementation groups. Genetical Research 33, 279–285.CrossRefGoogle ScholarPubMed
Bennett, D. (1975). The T-locus of the mouse. Cell 6, 441–454.CrossRefGoogle Scholar
Capanna, E., Gropp, A., Winking, H., Noack, G. & Civitelli, M. V. (1976). Robertsonian metacentrics in the mouse. Chromosoma 58, 341–353.CrossRefGoogle ScholarPubMed
Demin, J. S., Krjukov, V. I. & Orlov, V. N. (1979). Occurrence of t-haplotypes in natural populations of the house mouse (Mus musculus L.) in Tadzichistan. Dokl. Akad. Nauk USSR 248, 749–752 (in Russian).Google Scholar
Dooher, G. B., Berry, R. J., Artzt, K. & Bennett, D. (1981). A semilethal t-haplotype in the Orkney Islands. Genetical Research 37, 221–226.CrossRefGoogle ScholarPubMed
Dunn, L. C., Bennett, D. & Cookingham, J. (1973). Polymorphisms for lethal alleles in European populations of Mus musculus. Journal of Mammalogy 54, 822–830.CrossRefGoogle ScholarPubMed
Guenet, J.-L., Condamine, H., Gaillard, J. & Jacob, F. (1980). twPa-1, twPa-2, twPa-3: three new t–haplotypes in the mouse. Genetical Research 36, 211–217.CrossRefGoogle ScholarPubMed
Klein, J. (1975). Biology of the Mouse Histocompatibility-2 Complex. New York: Springer-Verlag.CrossRefGoogle Scholar
Klein, J. & Hammerberg, C. (1977). The control of differentiation by the T-complex. Immunological Reviews 33, 70–104.CrossRefGoogle ScholarPubMed
Lyon, M. F. (1981). The t-complex and the genetical control of development. Symposium of the Zoological Society. London 47, 71–104.Google Scholar
Mcneill, W. H. (1963). The Rise of the West. New York: The New Americas Library.Google Scholar
Müller-Beck, H. (1983). Urgeschichte in Baden Württenberg, Stuttgart: Konrad Theiss Verlag.Google Scholar
Nižetič, D., Figueroa, F. & Klein, J. (1984). Evolutionary relationships between the t and H-2 haplotypes in the house mouse. Immunogenetics 19, 311–320.CrossRefGoogle Scholar
Sage, R. D. (1981). Wild mice. In The Mouse in Biomedical Research, vol. I (ed. Foster, H. L., Small, I. D. and Fox, I. D.), pp. 39–90. New York: Academic Press.Google Scholar
Silver, L. M. & Artzt, K. (1981). Recombination suppression of mouse t–haplotypes is due to chromatin ‘mismatching’. Nature 290, 68–70.CrossRefGoogle ScholarPubMed
Sturm, S., Figueroa, F. & Klein, J. (1982). The relationship between t and H-2 complexes in wild mice. I. The H-2 haplotypes of 20 t-bearing strains. Genetical Research 40, 73–88.CrossRefGoogle ScholarPubMed
Winking, H. (1978). Mouse News Letter 59, 33.Google Scholar