Hostname: page-component-745bb68f8f-l4dxg Total loading time: 0 Render date: 2025-01-27T02:34:00.376Z Has data issue: false hasContentIssue false
  • English
  • Français

Polymorphism at the G6PD and 6PGD loci in Drosophila melanogaster: I. Evidence for selection in experimental populations

Published online by Cambridge University Press:  14 April 2009

R. Bijlsma  and
W. van Delden
R. Bijlsma
Affiliation:
Biological Centre, Department of Genetics, University of Groningen, Haren (Gn.), The Netherlands
W. van Delden
Affiliation:
Biological Centre, Department of Genetics, University of Groningen, Haren (Gn.), The Netherlands
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Gene frequency changes were followed in 17 experimental cage populations of Drosophila melanogaster polymorphic for the two loci G6PD and 6PGD. From these cages it was observed that selection was favouring the F alleles of both loci when the cages were started with low frequencies of these alleles (0·20F and 0·50F). A viability experiment and an extinction experiment also provided evidence that the F alleles of both loci were favoured. It is argued that the observed selection is not due to selective differences in genetic background of the different alleles, but is acting on the isozyme loci themselves.

Type
Research Article
Information
Genetics Research , Volume 30 , Issue 3 , December 1977 , pp. 221 - 236
Copyright
Copyright © Cambridge University Press 1977

References

REFERENCES

Ayala, F. J. (1972). Darwinian versus non-Darwinian evolution in natural populations of Drosophila. Proceedings of the Sixth Berkeley Symposium on Mathematical Statistics and Probability 5, 211–236.Google Scholar
Beardmore, J. A., Van Delden, W. & Alkema, L. (1963). A population cage for incubator use. Drosophila Information Service 37, 137–138.Google Scholar
Berger, E. H. (1970). A comparison of gene–enzyme variation between D. melanogaster and D. simulans. Genetics 66, 672–683.CrossRefGoogle ScholarPubMed
Bijlsma-Meeles, E. & Van Delden, W. (1974). Intra- and inter-population selection concerning the Alcoholdehydrogenase locus in Drosophila melanogaster. Nature 247, 369–371.CrossRefGoogle Scholar
Clarke, B. (1970). Darwinian evolution of proteins. Science 168, 1009–1011.CrossRefGoogle ScholarPubMed
Crow, J. F. & Kimura, M. (1970). An Introduction to Population Genetics Theory. New York: Harper and Row.Google Scholar
De Jong, G., Hoorn, A. J. W., Thörig, G. E. W. & Scharloo, W. (1972). Frequencies of Amylase variants in Drosophila melanogaster. Nature 238, 453–454.CrossRefGoogle ScholarPubMed
De Jong, G. & Scharloo, W. (1976). Environmental determination of selective significance or neutrality of Amylase variants in Drosophila melanogaster. Genetics 84, 77–94.CrossRefGoogle ScholarPubMed
Dickinson, W. J. & Sullivan, D. T. (1975). Gene–enzyme systems in Drosophila. Berlin–Heidelberg: Springer-Verlag.CrossRefGoogle Scholar
Geer, B. W., Kamiak, S. N., Kidd, K. R., Nishimura, R. A. & Yemm, S. J. (1976). Regulation of oxidative NADP-enzyme tissue levels in Drosophila melanogaster. I. Modulation by dietary carbohydrate and lipid. Journal of Experimental Zoology 195, 15–32.CrossRefGoogle ScholarPubMed
Jones, J. S. & Yamazaki, T. (1974). Genetic background and the fitness of allozymes. Genetics 78, 1185–1189.CrossRefGoogle ScholarPubMed
Kimura, M. (1968). Genetic variability maintained in a finite population, due to mutational production of neutral and nearly neutral isoalleles. Genetical Research 11, 247–269.CrossRefGoogle Scholar
Kimura, M. & Ohta, T. (1971). Protein polymorphism as a phase of molecular evolution. Nature 229, 467–469.CrossRefGoogle ScholarPubMed
King, J. L. & Jukes, T. H. (1969). Non-Darwinian evolution. Science 164, 788–798.CrossRefGoogle ScholarPubMed
Lewontin, R. C. (1974). Population Genetics. Annual Review of Genetics 7, 1–17.CrossRefGoogle Scholar
MacIntyre, R. J. (1972). Studies of enzyme evolution by subunit hybridization. Proceedings of the Sixth Berkeley Symposium on Mathematical Statistics and Probability 5, 129–154.Google Scholar
Newsholme, E. A. & Start, C. (1973). Regulation in Metabolism. London: John Wiley and Sons.Google Scholar
O'Brien, S. J. & MacIntyre, R. J. (1969). An analysis of gene–enzyme variability in natural populations of Drosophila melanogaster and D. simulans. American Naturalist 103, 97–113.CrossRefGoogle Scholar
Prakash, S., Lewontin, R. C. & Hubby, J. L. (1969). A molecular approach to the study of genie heterozygosity in natural populations. IV. Patterns of genie variation in central, marginal and isolated populations of Drosophila pseudoobscura. Genetics 61, 841–858.CrossRefGoogle Scholar
Singh, R. S., Hubby, J. L. & Lewontin, R. C. (1974). Molecular heterosis for heat-sensitive enzyme alleles. Proceedings of the National Academy of Sciences 71, 1808–1810.CrossRefGoogle ScholarPubMed
Van Delden, W., Kamping, A. & Van Dijk, H. (1975). Selection at the alcoholdehydrogenase locus in Drosophila melanogaster. Experientia 31, 418–419.CrossRefGoogle ScholarPubMed
Weber, G., Lea, M. A., Hird Convery, H. J. & Stamm, N. B. (1967). Regulation of gluconeogenesis and glycolysis: studies of mechanisms controlling enzyme activity. Advances in Enzyme Regulation 5, 257–298.CrossRefGoogle ScholarPubMed
Yamazaki, T. (1971). Measurement of fitness at the esterase-5 locus in Drosophila pseudoobscura. Genetics 67, 579–603.CrossRefGoogle ScholarPubMed
Young, W. J. (1966). X-linked electrophoretic variation in 6-phosphogluconate dehydrogenase. Journal of Heredity 57, 58–60.CrossRefGoogle Scholar
Young, W. J., Porter, J. E. & Childs, B. (1964). Glucose-6-phosphate dehydrogenase in Drosophila: X-linked electrophoretic variants. Science 143, 140–141.CrossRefGoogle ScholarPubMed