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Polarized negative interference in the paba 1 region of Aspergillus nidulans

Published online by Cambridge University Press:  14 April 2009

Obaid H. Siddiqi  and
A. Putrament
Obaid H. Siddiqi
Affiliation:
Department of Genetics, The University, Glasgow
A. Putrament
Affiliation:
Department of Genetics, The University, Glasgow
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The intensity of negative interference in 28 crosses involving 14 allelic paba mutants in different combinations has been measured. Among selected cross-overs between two such mutants, when the distance between the mutants is large, additional exchanges on the distal side (relative to the centromere) greatly exceed those on the proximal side. With decreasing length of the interval of selection, the inequality disappears. It is suggested that this polarity may be the outcome of a undirectional process which imposes a time sequence on the recombination events within an effectively paired segment. Some alternative explanations of this result are discussed.

Type
Research Article
Information
Genetics Research , Volume 4 , Issue 1 , February 1963 , pp. 12 - 20
Copyright
Copyright © Cambridge University Press 1963

References

REFERENCES

Calef, E. (1957). Effect on linkage maps of selection of crossovers between closely linked markers. Heredity, 11, 265–279.CrossRefGoogle Scholar
Chase, M. & Doermann, A. H. (1958). High negative interference over short segments of the genetic structure of bacteriophage T4. Genetics, 43, 332–353.CrossRefGoogle ScholarPubMed
Ephrussi-Taylor, H. (1960). Recombination analysis in microbial systems. Growth Molecule, Cell, Organism Symposium, Purdue University, Lafayette, Indiana.Google Scholar
Hershey, A. D. (1958). The production of recombinants in phage crosses. Cold Spr. Harb. Symp. quant. Biol. 18, 19–46.CrossRefGoogle Scholar
Käfer, E. (1958). An 8-chromosome map of Aspergillus nidulans. Advanc. Genet. 9, 105–145.CrossRefGoogle ScholarPubMed
Lacks, S. & Hotchkiss, R. D. (1960). A study of the genetic material determining an enzyme activity in Pneumococcus. Biochim. biophys. Acta, 39, 508–518.CrossRefGoogle Scholar
Lissouba, P. & Rizet, G. (1960). Sur l'existence d'une unité genetique polarisée ne subissent que des échanges non reciproques. C. R. Acad. Sci., Paris, 250, 3408–3410.Google Scholar
Pritchard, R. H. (1955). The linear arrangement of a series of alleles of Aspergillus nidulans. Heredity, 9, 343–371.CrossRefGoogle Scholar
Pritchard, R. H. (1957). Localized negative interference in Aspergillus nidulans. Microbial Gen. Bull. 15, 22–24.Google Scholar
Pritchard, R. H. (1960). Localized negative interference and its bearing on models of gene recombination. Genet. Res.. 1, 1–24.CrossRefGoogle Scholar
Siddiqi, O. H. (1962). The fine genetic structure of the pabal region of Aspergillus nidulans. Genet. Res.. 3, 69–89.CrossRefGoogle Scholar
Suyama, Y., Munkres, K. D. & Woodward, V. W. (1959). Genetic analysis of the pyr3 locus of Neurospora crassa: The bearing of recombination and gene conversion upon interallelic linearity. Genetica, 30, 293–311.CrossRefGoogle Scholar