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Physiological genetics of melanotic tumours in Drosophila melanogaster: VIII. The role of choline in the expression of the tumour gene tu bw and of its suppressor, su-tu

Published online by Cambridge University Press:  14 April 2009

John C. Sparrow  and
James H. Sang
John C. Sparrow
Affiliation:
Department of Biology, University of York, Heslington, York
James H. Sang
Affiliation:
School of Biological Sciences, University of Sussex, Brighton, England

Summary

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The melanotic tumour gene tu bw of Drosophila melanogaster has a specific suppressor su-tu. The genotypes tu bw; +su-tu and tu bw; su-tu show opposite responses, as measured by tumour penetrance, to increasing choline levels in the defined axenic medium. The three major metabolic functions of choline have been examined using additions to the axenic medium to determine which biochemical pathway(s) are different in the two genotypes. It is concluded that the opposite strain responses are due to changes in the pattern of phospholipid synthesis, and that the gene product of the su-tu gene probably functions in this area of metabolism.

Type
Research Article
Information
Genetics Research , Volume 24 , Issue 2 , October 1974 , pp. 215 - 227
Copyright
Copyright © Cambridge University Press 1974

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