Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-29T18:57:14.723Z Has data issue: false hasContentIssue false
  • English
  • Français

The phenogenetics of hair mutants in the house mouse: Opossum and Ragged *†

Published online by Cambridge University Press:  14 April 2009

Stanley J. Mann
Stanley J. Mann
Affiliation:
Biological Station, Roswell Park Memorial Institute, New York State Department of Health, Springville, New York and Biology Department, Brown University, Providence, Rhode Island
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The development and morphology of the semi-dominant mutations Ragged and Opossum are compared. The results of the present study support evidence of previous linkage studies which suggest that Ragged (Ra) and Opossum (Raop) are alleles.

2. Examination of embryos from 18-day-old first parity matings of + + × Raop + reveals that there is no deficiency of Raop + embryos. However, in Ra + × Raop + and Raop + × Raop + matings some Raop + embryos die in utero in addition to the pre-natal death of the RaRaop and RaopRaop embryos.

3. In all matings of Ragged and Opossum, there is a high frequency of oedematous Raop + embryos. In + + × Raop + matings, the frequency of oedema increases with increased age of the embryos.

4. Although the pattern of hair follicle formation is the same in both the mutant and normal embryos, follicles begin initiation later in the mutant embryos. The delay in follicle initiation is increased in the following order: Ra +, Raop + (non-oedemic), RaRa and Raop + (oedemic).

5. Heterozygous Opossum and Ra + mice have a full complement of pelage follicle primordia, but some follicles fail to differentiate. The differentiating follicles pass through the same developmental stages and require the same time for development as follicles in + + mice.

6. Heterozygous Ragged and Raop + mice have a full complement of tylotrichs, whereas the concentration of awls is variable. In Ra + mice there is a reduction in zigzags, and Raop + mice usually lack zigzags. No auchenes are observed in the mutant mice.

7. Hair growth is asynchronous in Ra + and Raop + mice, with the exception of the first pelage coat. The quiescent phase of the hair growth cycle is short or even missing.

8. The degree of Ra and Raop gene activity is in the following order of increased severity: Ra +, Raop + (semi-lethal), RaRa (semi-lethal), RaRaop (lethal) and RaopRaop (lethal).

Type
Research Article
Information
Genetics Research , Volume 4 , Issue 1 , February 1963 , pp. 1 - 11
Copyright
Copyright © Cambridge University Press 1963

References

REFERENCES

Carter, T. C. & Phillips, R. J. S. (1954). Ragged, a semidominant coat texture mutant in the house mouse. J. Hered. 45, 151–154.CrossRefGoogle Scholar
Chase, H. B. & Mann, S. J. (1960). Phenogenetic aspects of some hair and pigment mutants. J. cell comp. Physiol. 56, (suppl. 1), 103–112.CrossRefGoogle Scholar
Chase, H. B., Rauch, H. & Smith, V. W. (1951). Critical stages of hair development and pigmentation in the mouse. Physiol. Zool. 24, 1–8.CrossRefGoogle ScholarPubMed
Conn, H. J. & Darrow, M. A. (1946). Staining Procedures Used by the Biological Stain Commission, pp. 1c–28, 29. Biotech. Pub., Geneva, N.Y.Google Scholar
Danforth, C. H. (1925). Hair in its relation to questions of homology and phylogény. Amer. J. Anat. 36, 47–68.CrossRefGoogle Scholar
Dry, F. W. (1926). The coat of the mouse (Mus musculus). J. Genet. 16, 287–340.CrossRefGoogle Scholar
Dun, R. B. (1958). Growth of the mouse coat. VI. Distribution and number of vibrissae in the house mouse. Aust. J. Biol. Sci. 11, 95–105.CrossRefGoogle Scholar
Dun, R. B. (1959). The development and growth of vibrissae in the house mouse with particular reference to the time of action of the Tabby (Ta) and Ragged (Ra) genes. Aust. J. Biol. Sci. 12, 312–330.CrossRefGoogle Scholar
Green, E. L. & Mann, S. J. (1961). Opossum, a semi-dominant lethal mutation affecting hair and other characteristics of mice. J. Hered. 52, 223–227.CrossRefGoogle Scholar
Grüneberg, H. (1943). The development of some external features in mouse embryos. J. Hired. 34, 88–92.Google Scholar
Mann, S. J. (1962). Prenatal formation of hair follicle types. Anat. Rec. 144 (in press).CrossRefGoogle Scholar
Pinkus, F. (1905). Über Hautsinnesorgane neben dem menschlichen Haar (Haarscheiben) und ihre vergleichend-anatomische Bedeutung. Arch. mikr. Anat. 65, 121–179.CrossRefGoogle Scholar
Slee, J. (1957 a). The morphology and development of ‘Ragged’—a mutant affecting the skin and hair of the house mouse. I. Adult morphology. J. Genet. 55, 100–121.CrossRefGoogle Scholar
Slee, J. (1957 b). The morphology and development of ragged—a mutant affecting the skin and hair of the house mouse. II. Genetics, embryology and gross juvenile morphology. J. Genet. 55, 570–584.CrossRefGoogle Scholar
Straile, W. E. (1960). Sensory hair follicles in mammalian skin: the tylotrich follicle. Amer. J. Anat. 106, 133–148.Google Scholar