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P-element-induced mutation and quantitative variation in Drosophila melanogaster: lack of enhanced response to selection in lines derived from dysgenic crosses.

Published online by Cambridge University Press:  14 April 2009

A. Torkamanzehi ,
C. Moran  and
F. W. Nicholas
A. Torkamanzehi*
Affiliation:
Department of Animal Husbandry, The University of Sydney, N.S.W. 2006, Australia
C. Moran
Affiliation:
Department of Animal Husbandry, The University of Sydney, N.S.W. 2006, Australia
F. W. Nicholas
Affiliation:
Department of Animal Husbandry, The University of Sydney, N.S.W. 2006, Australia
*
† Corresponding authors.
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Dysgenic and non-dysgenic base populations were made by reciprocal crossing of Harwich (P) and Canton-S (M) strains. From each cross, two up and two down selection lines were established, with selection on abdominal bristle number for ten generations. The intensity of selection was 10 out of 50 individuals from each sex. Mean bristle number, phenotypic variation and heritabilities were compared between dysgenic and non-dysgenic populations under selection. Except for an anomalous non-dysgenic downline in which a mutation of large effect occurred, all lines showed similar responses to selection. These results contrast with the results reported by Mackay (1984, 1985) in which substantial increases were obtained for response to selection, phenotypic variation and heritability in the dysgenic compared to non-dysgenic lines. There are some indications that the higher response in our aberrant non-dysgenic downline is the result of transposition. Possible explanations for the occurrence of transposition and dysgenesis in the lines derived from nondysgenic crosses are discussed.

Type
Research Article
Information
Genetics Research , Volume 51 , Issue 3 , June 1988 , pp. 231 - 238
Copyright
Copyright © Cambridge University Press 1988

References

Bregliano, J. C. & Kidwell, M. G. (1983). Hybrid dysgenesis determinants. In Mobile Genetic Elements (ed. Shapiro, J. A.), pp. 363–410. London, New York: Academic Press.Google Scholar
Clayton, G. A. & Robertson, A. (1955). Mutation and quantitative variation. American Naturalist 89, 151–158.CrossRefGoogle Scholar
Clayton, G. A. & Robertson, A. (1964). The effects of X-rays on quantitative characters. Genetical Research 5, 410–422.CrossRefGoogle Scholar
Enfield, F. D. (1986). Quantitative genetic variation from new mutations in Tribolium. Proceedings of 3rd World Congress on Genetics Applied to Livestock Production 12, 144–151.Google Scholar
Engels, W. R. (1979 a). Hybrid dysgenesis in Drosophila melanogaster: rules of inheritance of female sterility. Genetical Research 33, 219–236.CrossRefGoogle Scholar
Engels, W. R. (1979 b). The estimation of mutation rates when premeiotic events are involved. Environmental Mutagenesis 1, 37–43.CrossRefGoogle ScholarPubMed
Engels, W. R. (1983). The P family of transposable elements in Drosophila. Annual Review of Genetics 17, 315–344.CrossRefGoogle Scholar
Engels, W. R. (1984). A trans-acting product needed for P factor transposition in Drosophila. Science 226, 1194–1196.CrossRefGoogle ScholarPubMed
Frankham, R. (1980). Origin of genetic variation in selection lines. In Selection Experiments in Laboratory and Domestic Animals (ed. Robertson, A.), pp. 56–68. Slough: Commonwealth Agricultural Bureaux.Google Scholar
Green, M. M. (1984). Genetic instability in Drosophila melanogaster: on the identity of the MR and P–M systems. Biologisches Zentralblatt 103, 1–8.Google Scholar
Hill, W. G. (1972). Estimation of realised heritabilities from selection experiments. I. Divergent selection. Biometrics 28, 747–765.CrossRefGoogle ScholarPubMed
Hill, W. G. (1982). Prediction of response to artificial selection from new mutations. Genetical Research 40, 255–278.CrossRefGoogle ScholarPubMed
Hollingdale, B. & Barker, J. S. F. (1971). Selection for increased abdominal bristle number in Drosophila melanogaster with concurrent irradiation. I. Populations derived from an inbred line. Theoretical and Applied Genetics 41, 208–215.CrossRefGoogle ScholarPubMed
Kidwell, M. G., Kidwell, J. F. & Sved, J. A. (1977). Hybrid dysgenesis in Drosophila melanogaster: a syndrome of aberrant traits including mutation, sterility and male recombination. Genetics 86, 813–833.CrossRefGoogle ScholarPubMed
Kidwell, M. G., Novy, J. B. & Feely, S. M. (1981). Rapid unidirectional change of hybrid dysgenesis potential in Drosophila. Heredity 72, 32–38.CrossRefGoogle ScholarPubMed
Kitagawa, O. (1967). The effects of X-ray irradiation on selection response in Drosophila melanogaster. Japanese Journal of Genetics 42, 121–137.Google Scholar
Kiyasu, P. K. & Kidwell, M. G. (1984). Hybrid dysgenesis in Drosophila melanogaster: the evolution of mixed P and M populations maintained at high temperature. Genetical Research 44, 251–259.CrossRefGoogle Scholar
Lindsley, D. L. & Grell, E. H. (1968). Genetic Variation of Drosophila melanogaster. Carnegie Institute of Washington, Publication no. 627.Google Scholar
Mackay, T. F. C. (1984). Jumping genes meet abdominal bristles: hybrid dysgenesis-induced quantitative variation in Drosophila melanogaster. Genetical Research 44, 231–237.CrossRefGoogle Scholar
Mackay, T. F. C. (1985). Transposable element-induced response to artificial selection in Drosophila melanogaster. Genetics 111, 351–374.CrossRefGoogle ScholarPubMed
Mackay, T. F. C. (1986). Transposable element-induced fitness mutations in Drosophila melanogaster. Genetical Research 48, 77–87.CrossRefGoogle Scholar
Mackay, T. F. C. (1987 a). Transposable element-induced polygenic mutations in Drosophila melanogaster. Genetical Research 49, 225–233.CrossRefGoogle Scholar
Mackay, T. F. C. (1987 b). Transposable element-induced quantitative genetic variation in Drosophila. Proceedings of the Second International Conference on Quantitative Genetics.Raleigh,North Carolina (in press).Google Scholar
McClintock, B. (1956). Controlling elements and the gene. Cold Spring Harbor Symposium on Quantitative Biology 21, 197–216.CrossRefGoogle ScholarPubMed
Morton, R. A. & Hall, S. C. (1985). Response of dysgenic and non-dysgenic populations to malathion exposure. Drosophila Information Service 61, 126–128.Google Scholar
O'Hare, K. & Rubin, G. M. (1983). Structures of P transposable elements and their sites of insertion and excision in the Drosophila melanogaster genome. Cell 34, 25–35.CrossRefGoogle ScholarPubMed
Preston, C. R. & Engels, W. R. (1984). Movement of P elements within a P strain. Drosophila Information Service 60, 169–170.Google Scholar
Pardue, M. L. (1986). In situ hybridization to DNA of chromosomes and nuclei. In Drosophila: A Practical Approach (ed. Roberts, D. B.), pp. 111–137. Oxford: IRL Press.Google Scholar
Ronsseray, S. (1986). P–M system of hybrid dysgenesis in Drosophila melanogaster: thermic modifications of the cytotype can be detected for several generations. Molecular and General Genetics 205, 23–27.CrossRefGoogle Scholar
Ronsseray, S., Anxolabehere, D. & Periquet, G. (1984). Hybrid dysgenesis in Drosophila melanogaster: influence of temperature on cytotype determination in the P–M system. Molecular and General Genetics 196, 17–23.CrossRefGoogle ScholarPubMed
Rubin, G. M. (1983). Dispersed repetitive DNA in Drosophila. In Mobile Genetic Elements (ed. Shapiro, J. A.), pp. 329–361. London, New York: Academic Press.Google Scholar
Rubin, G. M., Kidwell, M. G. & Bingham, P. M. (1982). The molecular basis of P–M hybrid dysgenesis: the nature of induced mutations. Cell 29, 987–994.CrossRefGoogle ScholarPubMed
Shapiro, J. A. (ed.) (1983). Mobile Genetic Elements. London, New York: Academic Press.Google Scholar
Shi, Y. (1986). Transposable elements, mutation and responses to selection in Drosophila melanogaster. M.Sc. Thesis. University of New England, Armidale, Australia.Google Scholar
Simmons, M. J. & Bucholz, L. M. (1985). Transposase titration in Drosophila melanogaster: a model for cytotype in the P–M system of hybrid dysgenesis. Proceedings of the National Academy of Sciences, U.S.A. 82, 8119–8123.CrossRefGoogle Scholar
Steel, R. G. D. & Torrie, J. H. (1981). Principles and Procedures of Statistics, a Biometrical Approach, 2nd ed.New York: McGraw-Hill.Google Scholar
Sved, J. A. (1979). The ‘hybrid dysgenesis syndrome’ in Drosophila melanogaster. Bioscience 29, 659–664.CrossRefGoogle Scholar
Sved, J. A. (1987). Hybrid dysgenesis in Drosophila melanogaster: evidence from sterility and Southern hybridisation tests that P cytotype is not maintained in the absence of chromosomal P factors. Genetics 115, 121–127.CrossRefGoogle Scholar