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Organization of polygenic systems: Cell death modifiers from natural populations of Drosophila melanogaster

Published online by Cambridge University Press:  14 April 2009

James N. Thompson Jr  and
William E. Spivey
James N. Thompson Jr
Affiliation:
Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019, U.S.A.
William E. Spivey
Affiliation:
Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019, U.S.A.
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Summary

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Expression of three wing-cell death mutants in Drosophila melanogaster was used to survey cryptic polygenic modifiers of cell death in wild type strains. Females carrying the X-linked mutants Beadex-3, notchoid and scalloped were crossed to males from each of 20 isofemale strains. Phenotypic variation in the amount of cell death was measured in F1 mutant males that were heterozygous for polygenic loci segregating in the wild strains. As expected, each mutant uncovered a broad range of polygenic variation among strains. Yet, when cluster analyses were used to evaluate the degree of correlation among the expressions of Bx3, sd and nd, the isofemale strains could be partitioned into a small number of groups that were similar in the effects they had upon the severity of cell death. Chromosome mapping of one cell death suppressor strain demonstrated that different polygenic loci could produce the same phenotype in different mutant backgrounds.

Type
Research Article
Information
Genetics Research , Volume 44 , Issue 3 , December 1984 , pp. 261 - 269
Copyright
Copyright © Cambridge University Press 1984

References

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