Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-27T01:40:03.391Z Has data issue: false hasContentIssue false
  • English
  • Français

On X inactivation in XO embryos of mammals

Published online by Cambridge University Press:  14 April 2009

H. Sharat Chandra
H. Sharat Chandra
Affiliation:
Institute for Genetic Studies, Bangalore, India
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

By analogy with the situation in coccids it is suggested that in mammalian XO embryos the single X turns heterochromatic in some cells, but that such a change does not result in cell death because the X then reverts back to an euchromatic and active state. This testable alternative to the Gartler–Sparkes hypothesis would imply that the anomalies of the XO Turner syndrome are largely due to imbalance of sex-linked genes rather than developmental damage resulting from cell death and that mammalian X inactivation might become reversed in response to special developmental needs.

Type
Short Papers
Information
Genetics Research , Volume 16 , Issue 2 , October 1970 , pp. 233 - 234
Copyright
Copyright © Cambridge University Press 1970

References

REFERENCES

Beutler, E. (1964). Gene inactivation: the distribution of gene products among populations of cells in heterozygous women. Cold Spring Harbor Symposium on Quantitative Biology 29, 261.CrossRefGoogle Scholar
Brown, S. W. (1966). Heterochromatin. Science, N.Y. 151, 417.CrossRefGoogle ScholarPubMed
Cattanach, B. M., Pollard, C. E. & Perez, J. N. (1969). Controlling elements in the mouse X-chromosome. I. Interaction with the X-linked genes. Genetical Research 14, 223.CrossRefGoogle ScholarPubMed
Chandra, H. S. (1963). Cytogenetic studies following high dosage paternal irradiation in the mealy bug, Planococcus citri. II. Cytology of X 1 females and the problem of lecanoid sex determination. Chromosoma 14, 330.CrossRefGoogle Scholar
Gartler, S. M. & Sparkes, R. S. (1963). The Lyon-Beutler hypothesis and isochromosome X patients with the Turner syndrome. Lancet ii, 411.CrossRefGoogle Scholar
Hecht, G. & Macfarlane, J. P. (1969). Mosaieism in Turner's syndrome reflects lethality of XO. Lancet ii, 1197.CrossRefGoogle Scholar
Lyon, M. F. (1961). Gene action in the X-chromosome of the mouse (Mus musculua L.). Nature 190, 372.CrossRefGoogle ScholarPubMed
Lyon, M. F., Searle, A. G., Ford, C. E. & Ohno, S. (1964). A mouse translocation suppressing sex-linked variegation. Cytogenetics 3, 306.CrossRefGoogle ScholarPubMed
Nur, U. (1967). Reversal of heterochromatization and the activity of the paternal chromosome set in the male mealy bug. Genetics 56, 375.CrossRefGoogle ScholarPubMed
Polani, P. E. & Polani, N. (1969). Chromosome anomalies, mosaicism and dermatoglyphic assymmetry. Annula of Human Genetics 32, 391.CrossRefGoogle Scholar