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Observations on a set of radiation-induced dominant T-like mutations in the mouse*

Published online by Cambridge University Press:  14 April 2009

Dorothea Bennett ,
L. C. Dunn ,
Martha Spiegelman ,
Karen Artzt ,
Janice Cookingham  and
Elizabeth Schermerhorn
Dorothea Bennett
Affiliation:
Cornell University Medical College, New York, N.Y., U.S.A.
L. C. Dunn
Affiliation:
Nevis Biological Station, Columbia University, Irvington-on-Hudson, N.Y., U.S.A.
Martha Spiegelman
Affiliation:
Cornell University Medical College, New York, N.Y., U.S.A.
Karen Artzt
Affiliation:
Cornell University Medical College, New York, N.Y., U.S.A.
Janice Cookingham
Affiliation:
Nevis Biological Station, Columbia University, Irvington-on-Hudson, N.Y., U.S.A.
Elizabeth Schermerhorn
Affiliation:
Nevis Biological Station, Columbia University, Irvington-on-Hudson, N.Y., U.S.A.
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Genetic analysis of seven dominant short tailed mutations independently induced by radiation of male mice showed that six were allelic to T (Brachyury) but not identical to it. Homozygotes for each mutant die at least 2 days earlier than T/T homozygotes; two that were studied histologically are indistinguishable from one another. The development of these abnormal embryos is arrested by seven days of gestation, when cells of embryonic ectoderm cease proliferation and become pycnotic. Endoderm and extra-embryonic ectoderm do not seem to be primarily affected, and survive and grow for at least 2 days more. Serological studies of one of these mutations suggest that it is a deletion. A review is presented of these and other T-like mutations that have been described; from this it appears that five different categories of T-like mutants are discernible.

Type
Research Article
Information
Genetics Research , Volume 26 , Issue 1 , August 1975 , pp. 95 - 108
Copyright
Copyright © Cambridge University Press 1975

References

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