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The number of loci affecting a quantitative trait in Drosophila melanogaster revealed by artificial selection

Published online by Cambridge University Press:  14 April 2009

Araceli Gallego  and
Carlos López-Fanjul
Araceli Gallego
Affiliation:
Departamento de Genética, Facultad de Biología, Universidad Complutense de Madrid, Madrid-3, Spain
Carlos López-Fanjul
Affiliation:
Departamento de Genética, Facultad de Biología, Universidad Complutense de Madrid, Madrid-3, Spain
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Summary

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Individual and within-full-sib family selection for low sternopleural bristle number was carried out for 17 generations, with six replicate lines for each selection method. Our results can be summarized as follows: (1) the response to selection was exhausted very quickly, (2) the additive variance of the selected lines declined rapidly, (3) the variation in response to selection decreased as selection progressed, (4) genetic differences among replicates at the selection limit were small, (5) individual selection resulted in a higher initial response than within-family selection, but similar limits were achieved with both procedures. These observations are consistent with the hypothesis that the pattern of response to selection is due to the segregation in the base population of only a few loci with large effects, at intermediate frequencies.

Type
Research Article
Information
Genetics Research , Volume 42 , Issue 2 , October 1983 , pp. 137 - 149
Copyright
Copyright © Cambridge University Press 1983

References

REFERENCES

Becker, W. A. (1975). Manual of Procedures in Quantitative Genetices. 3rd edition. Pullman: Washington State University PressGoogle Scholar
Bulmer, M. G. (1971). The effect of selection on genetic variability. American Naturalist 105, 201–211.CrossRefGoogle Scholar
Comstock, R. E. (1969). Number of genes affecting growth in mice. Genetics Lectures 1, 137–148Corvallis: Oregon State University Press.Google Scholar
Dempflé, L. (1975). A note on increasing the limit of selection through selection within families. Genetical Research 24, 127–135.Google Scholar
Falconer, D. S. (1973). Replicated selection for body weight in mice. Genetical Research 22, 291–321.CrossRefGoogle ScholarPubMed
Falconer, D. S. (1981). Introduction to Quantitative Genetics. London: Longman.Google Scholar
Gallego, A., García-Dorado, A. & López-Fanjul, C. (1982). A new allele (H st) at the Hairless locus with an effect on sternopleural bristle number. Drosophila Information Service 58, 64.Google Scholar
Hill, W. G. (1970). Design of experiments to estimate heritability by regression of offspring on selected parents. Biometrics 26, 565–571.CrossRefGoogle ScholarPubMed
Hill, W. G. (1972). Estimation of realised heritability from selection experiments. II. Selection in one direction. Biometrics 28, 767–780.Google Scholar
Hill, W. G. (1974). Variability of response to selection in genetic experiments. Biometrics 30, 363–366.Google Scholar
Hill, W. G. (1977). Variation in response to selection. Proceedings of the International Conference on Quantitative Genetics (ed. Pollak, E., Comstock, R. & Bailey, T. B.), pp. 343–365. Ames: Iowa State University Press.Google Scholar
James, J. W. (1962 a). The spread of genes in populations under selection. Proceedings of the XIIth World's Poultry Congress, pp. 14–16.Google Scholar
James, J. W. (1962 b). The spread of genes in random mating control populations. Genetical Research 3, 1–10.CrossRefGoogle Scholar
Lindsley, D. L. & Grell, E. H. (1968). Genetic variation in Drosophila melanogaster. Carnegie Institution of Washington. Publication No. 627.Google Scholar
López-Fanjul, C. & Hill, W. G. (1973). Genetic differences between populations of Drosophila melanogaster for a quantitative trait. I. Laboratory populations. Genetical Research 22, 51–68.CrossRefGoogle ScholarPubMed
López-Fanjul, C. & Domínguez, M. L. (1982). Étude expérimentale de la variabilité de la réponse à la sélection chez Drosophila melanogaster. Annales de Génétique et de Sélection Animale 14, 213–224.Google Scholar
McPhee, C. P. & Robertson, A. (1970). The effect of suppressing crossing-over on the response to selection in Drosophila melanogaster. Genetical Research 16, 1–16.Google Scholar
Madalena, F. E. & Robertson, A. (1975). Population structure in artificial selection: studies with Drosophila melanogaster. Genetical Research 24, 113–126.CrossRefGoogle Scholar
Punzoni, R. W. & James, J. W. (1978). Possible biasses in heritability estimates from intraclass correlation. Theoretical and Applied Genetics 53, 25–27.CrossRefGoogle Scholar
Reeve, E. C. R. (1961). A note on non-random mating in progeny tests. Genetical Research 2, 195–203.CrossRefGoogle Scholar
Robertson, A. (1960). A theory of limits in artificial selection. Proceedings of the Royal Society of London B 153, 234–249.Google Scholar
Robertson, A. (1961). Inbreeding in artificial selection programmes. Genetical Research 2, 189–194.CrossRefGoogle Scholar
Robertson, A. (1967). The nature of quantitative genetic variation. In Heritage from Mendel (ed. Brink, R. A.), pp. 265–280. Madison: University of Wisconsin Press.Google Scholar
Robertson, A. (1968). The spectrum of genetic variation. In Population Biology and Evolution (ed. Lewontin, R. C.), pp. 5–16. Syracuse: Syracuse University Press.Google Scholar
Sorensen, D. A. & Hill, W. G. (1982). Effect of short term directional selection on genetic variability: experiments with Drosophila melanogaster. Heredity 48, 27–33.Google Scholar
Young, S. S. Y. & Skavaril, R. V. (1976). Computer simulation of within family selection in finite populations. Theoretical and Applied Genetics 48, 45–51.Google Scholar