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A new t-complex embryonic lethal (tcl0) has arisen in the Thp chromosome of the mouse and is allelic to t0

Published online by Cambridge University Press:  14 April 2009

Edwin R. Sanchez  and
Craig Hammerberg
Edwin R. Sanchez
Affiliation:
Department of Human Genetics, Box 015, University of Michigan Medical School, Ann Arbor, Michigan 48109
Craig Hammerberg
Affiliation:
Department of Human Genetics, Box 015, University of Michigan Medical School, Ann Arbor, Michigan 48109
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Summary

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Complement testing of a Thp line revealed a failure of survival of Thp/t0 embryos. The genetic factor responsible for this lethality maps between Brachyury (T) and tufted (tf) on the murine seventeenth chromosome. This lethal factor permits recombination between T and tf and does not affect the transmission of its seventeenth chromosome. Its effect upon embryonic development is similar to that of the t0 haplotype. It would appear to represent a point mutation of a single gene, t-complex lethal zero (tcl0).

Type
Research Article
Information
Genetics Research , Volume 43 , Issue 1 , February 1984 , pp. 27 - 33
Copyright
Copyright © Cambridge University Press 1984

References

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