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A new regulatory gene in the histidine decarboxylase gene complex determines the responsiveness of the mouse kidney enzyme to testosterone

Published online by Cambridge University Press:  14 April 2009

Richard J. Middleton ,
S. A. M. Martin  and
Grahame Bulfield
Richard J. Middleton
Affiliation:
Gene Expression Group, AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian, EH25 9PS, U.K.
S. A. M. Martin
Affiliation:
Department of Genetics, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JN, U.K.
Grahame Bulfield*
Affiliation:
Gene Expression Group, AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian, EH25 9PS, U.K.
*
* Corresponding authors.
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Summary

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The level of histidine decarboxylase in mouse kidney normally differs between the sexes with females higher than males. In a strain derived from feral Danish mice (DAN), however, both males and females have the same, high, HDC activity due to the males being insensitive to repression by testosterone. Genetic analysis indicates that this insensitivity is caused by a variant allele of a new gene in the histidine decarboxylase gene complex, Hdc-a; the Hdc-ab allele in C57BL/10 confers high sensitivity to testosterone whereas the Hdc-aw allele in the DAN strain confers low sensitivity. In addition, the DAN strain has a novel haplotype for the other three known elements of [Hdc]: the allele Hdc-sd of the structural gene, the Hdc-cd allele of the gene determining enzyme concentration, and the oestrogen-inducible allele Hdc-eb.

Type
Research Article
Information
Genetics Research , Volume 49 , Issue 1 , February 1987 , pp. 61 - 67
Copyright
Copyright © Cambridge University Press 1987

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