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Multiple allelism at the locus controlling warfarin resistance in the Norway rat

Published online by Cambridge University Press:  14 April 2009

J. H. Greaves  and
P. B. Ayres
J. H. Greaves
Affiliation:
Tolworth Laboratory, Ministry of Agriculture, Fisheries and Food, Hook Rise South, Tolworth, Surrey KT6 7NF
P. B. Ayres
Affiliation:
Tolworth Laboratory, Ministry of Agriculture, Fisheries and Food, Hook Rise South, Tolworth, Surrey KT6 7NF
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Summary

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Two warfarin-resistant strains of the Norway rat, Rattus norvegicus, derived independently from wild populations in Wales and Scotland and both homozygous for a major gene at the warfarin-resistance locus, Rw, were found to differ in their hypoprothrombinaemic response to simultaneous dosage with warfarin and vitamin K. The Welsh strain gave a small response and the Scottish strain a large response. These two response levels segregated in Mendelian fashion in various crosses involving the two resistant strains and a third, non-resistant strain. This indicates that the Rw locus has a series of three multiple alleles, denoted Rww, Rws and Rw+. The results are discussed briefly in relation to biochemical, ecological and evolutionary aspects of warfarin resistance.

Type
Research Article
Information
Genetics Research , Volume 40 , Issue 1 , August 1982 , pp. 59 - 64
Copyright
Copyright © Cambridge University Press 1982

References

REFERENCES

Bell, R. G. (1978). Metabolism of vitamin K and prothrombin synthesis: anticoagulants and the vitamin K-epoxide cycle. Federation Proceedings: American Societies for Experimental Biology 37, 2599–2604.Google ScholarPubMed
Bell, R. G. & Caldwell, P. T. (1973). Mechanism of warfarin resistance. Warfarin and the metabolism of vitamin K1. Biochemistry 12, 1759–1762.CrossRefGoogle Scholar
Festing, M. F. W. (1978). Nomenclature. Rat News Letter 4, 1–3, 10–12.Google Scholar
Fasco, M. J. & Principe, L. M. (1980). Vitamin K1 hydroquinone formation catalyzed by a microsomal reductase system. Biochemical and Biophysical Research Communications 97, 1487–1492.CrossRefGoogle ScholarPubMed
Greaves, J. H. & Ayres, P. (1973). Warfarin resistance and vitamin K requirement in the rat. Laboratory Animals 7, 141–148.CrossRefGoogle ScholarPubMed
Greaves, J. H. & Ayres, P. B. (1976). Inheritance of Scottish-type resistance to warfarin in the Norway rat. Genetical Research 28, 231–239.CrossRefGoogle ScholarPubMed
Greaves, J. H. & Ayres, P. B. (1977). Unifactorial inheritance of warfarin resistance in Battus norvegicus from Denmark. Genetical Research 29, 215–222.CrossRefGoogle Scholar
Greaves, J. G., Redfern, R., Ayres, P. B. & Gill, J. E. (1977). Warfarin resistance: a balanced polymorphism in the Norway rat. Genetical Research 30, 257–263.CrossRefGoogle ScholarPubMed
Martin, A. D. (1973). Vitamin K requirement and anticoagulant response in the warfarin resistant rat. Biochemical Society Transactions 1, 1206–1208.CrossRefGoogle Scholar
O'Reilly, R. A. (1971). Vitamin K in hereditary resistance to oral anticoagulant drugs. American Journal of Physiology 221, 1327–1330.CrossRefGoogle ScholarPubMed
Partridge, G. G. (1979). Relative fitness of genotypes in a population of Rattus norvégiens polymorphic for warfarin resistance. Heredity 43, 239–246.CrossRefGoogle Scholar
Partridge, G. G. (1980). Vitamin K deficiency syndromes in warfarin-resistant brown rats (Rattus norvegicus). Laboratory Animals 14, 193–195.CrossRefGoogle ScholarPubMed
Redfern, R. & Gill, J. E. (1978). The development and use of a test to identify resistance to the anticoagulant difenacoum in the Norway rat (Rattus norvegicus). Journal of Hygiene 81, 427–431.CrossRefGoogle Scholar
Zimmerman, A. & Matschiner, J. T. (1972). The biochemical basis of hereditary resistance to warfarin in the rat. Federation Proceedings: American Societies for Experimental Biology 31, 405.Google Scholar
Zimmerman, A. & Matschiner, J. T. (1974). Biochemical basis of hereditary resistance to warfarin in the rat. Biochemical Pharmacology 23, 1033–1040.CrossRefGoogle Scholar