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Multiple allelism at the locus controlling warfarin resistance in the Norway rat

Published online by Cambridge University Press:  14 April 2009

J. H. Greaves  and
P. B. Ayres
J. H. Greaves
Affiliation:
Tolworth Laboratory, Ministry of Agriculture, Fisheries and Food, Hook Rise South, Tolworth, Surrey KT6 7NF
P. B. Ayres
Affiliation:
Tolworth Laboratory, Ministry of Agriculture, Fisheries and Food, Hook Rise South, Tolworth, Surrey KT6 7NF
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Summary

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Two warfarin-resistant strains of the Norway rat, Rattus norvegicus, derived independently from wild populations in Wales and Scotland and both homozygous for a major gene at the warfarin-resistance locus, Rw, were found to differ in their hypoprothrombinaemic response to simultaneous dosage with warfarin and vitamin K. The Welsh strain gave a small response and the Scottish strain a large response. These two response levels segregated in Mendelian fashion in various crosses involving the two resistant strains and a third, non-resistant strain. This indicates that the Rw locus has a series of three multiple alleles, denoted Rww, Rws and Rw+. The results are discussed briefly in relation to biochemical, ecological and evolutionary aspects of warfarin resistance.

Type
Research Article
Information
Genetics Research , Volume 40 , Issue 1 , August 1982 , pp. 59 - 64
Copyright
Copyright © Cambridge University Press 1982

References

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