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Mitochondrial genetics, circular DNA and the mechanism of the petite mutation in yeast

Published online by Cambridge University Press:  14 April 2009

G. D. Clark-Walker  and
George L. Gabor Miklos
G. D. Clark-Walker
Affiliation:
Departments of Developmental Biology and Genetics, Research School of Biological Sciences, The Australian National University, Canberra, A.C.T. 2601, Australia
George L. Gabor Miklos
Affiliation:
Departments of Developmental Biology and Genetics, Research School of Biological Sciences, The Australian National University, Canberra, A.C.T. 2601, Australia
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Summary

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We propose a general hypothesis involving properties of circular DNA which can explain such phenomena as the petite mutation, suppressiveness, and the polarity observed in mitochondrial recombination in the yeast Saccharomyces cerevisiae. This hypothesis involves excision and insertion events between circular DNA molecules as well as structural rearrangements in the DNA generated by these events. The special properties of circular DNA have been considered in analysing recombination, and a number of results are obtained which are not intuitively apparent.

This hypothesis can be applied to any situation involving circular DNA such as bacterial plasmids and cytoplasmic circular DNAs, where the opportunity exists for recombination and rearrangement events.

Type
Research Article
Information
Genetics Research , Volume 24 , Issue 1 , August 1974 , pp. 43 - 57
Copyright
Copyright © Cambridge University Press 1974

References

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