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Meiotic drive in female mice heterozygous for the HSR inserts on chromosome 1

Published online by Cambridge University Press:  14 April 2009

Sergei I. Agulnik ,
Alexander I. Agulnik  and
Anatoly O. Ruvinsky
Sergei I. Agulnik
Affiliation:
Institute of Cytology and Genetics, Academy of Sciences of the USSR, Siberian Division, Novosibirsk-90
Alexander I. Agulnik
Affiliation:
Institute of Cytology and Genetics, Academy of Sciences of the USSR, Siberian Division, Novosibirsk-90
Anatoly O. Ruvinsky*
Affiliation:
Institute of Cytology and Genetics, Academy of Sciences of the USSR, Siberian Division, Novosibirsk-90
*
* Corresponding author.
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Chromosome 1 with one or two long insertions has been previously found in natural mouse populations. The inheritance of chromosome 1 with two insertions from the Yakutsk population is analysed in this paper. It was demonstrated that heterozygous females transmit this chromosome to 80–85% of offspring. The observations made at M II, in conjunction with the recombination data, allowed us to conclude that preferential passage of the chromosome 1 with insertions to the oocyte and egg, rather than to the first and second polar bodies at meiosis, is the causative factor of the distorted segregation. A meiotic drive of such potency has not been previously reported for female mammals. The possible mechanism of the drive is discussed.

Type
Research Article
Information
Genetics Research , Volume 55 , Issue 2 , April 1990 , pp. 97 - 100
Copyright
Copyright © Cambridge University Press 1990

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