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Mechanism of infertility in t-complex mice

Published online by Cambridge University Press:  14 April 2009

J. R. Archer ,
S. J. Self  and
B. G. Winchester
J. R. Archer
Affiliation:
Searle Research Laboratories, High Wycombe, Bucks
S. J. Self
Affiliation:
Department of Biochemistry, Queen Elizabeth College, London
B. G. Winchester
Affiliation:
Department of Biochemistry, Queen Elizabeth College, London
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Sperm from mice heterozygous (t/+) for many t-lethal haplotypes show segregation distortion. More offspring inherit the t-haplotype than the normal wild haplotype. In contrast males heterozygous (tx/tv) for two t-lethal haplotypes are sterile although they produce normal-looking sperm. The experiments were undertaken to show whether sperm from tx/tv mice are the same as t-fertile sperm from t/+. Female albino mice were persuaded to mate first with coloured sterile tx/tv heterozygotes and then with normal white +/+ males. With the exception of one litter (from a t-heterozygous male which proved to have been misidentified) all the progeny were derived from the mating with the normal father. We conclude that t-bearing sperm from t-lethal (tx/tv) heterozygotes are inviable, and different from t-sperm in t/+ heterozygotes.

Type
Research Article
Information
Genetics Research , Volume 32 , Issue 1 , August 1978 , pp. 79 - 84
Copyright
Copyright © Cambridge University Press 1978

References

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