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The liver/erythrocyte pyruvate kinase gene complex [Pk-1] in the mouse: regulatory gene mutations

Published online by Cambridge University Press:  14 April 2009

Lesley A. Fitton ,
Morag Davidson ,
Karen J. Moore ,
Daniel J. Charles ,
Walter Pretsch ,
Robert C. Elston  and
Graham Bulfield
Lesley A. Fitton
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Roslin, Midlothian, EH25 9PS
Morag Davidson
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Roslin, Midlothian, EH25 9PS
Karen J. Moore
Affiliation:
Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research Facility, P.O. Box B, Frederick MD, 21702, USA
Daniel J. Charles
Affiliation:
Institut für Süugetiergenetik, Gesellschaft für Strahlen- und Umweltforschung, D-8042 Neuherberg, Federal Republic of, Germany
Walter Pretsch
Affiliation:
Institut für Süugetiergenetik, Gesellschaft für Strahlen- und Umweltforschung, D-8042 Neuherberg, Federal Republic of, Germany
Robert C. Elston
Affiliation:
Department of Biometry and Genetics, LouisianaState University Medical Center, New Orleans, LA 70112, U.S.A.
Graham Bulfield*
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Roslin, Midlothian, EH25 9PS
*
*Corresponding author.
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Summary

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Nine enzyme activity variants and one charge variant of liver/erythrocyte pyruvate kinase have been found amongst laboratory and wild mice. Four of the enzyme activity variants were previously reported to be caused by allelic differences in the structural gene, Pk-ls. Analysis of two putative regulatory gene mutations is now reported, both of which map at, or close to, the structural gene on chromosome 3. One of these mutations, in the inbred strain SWR, is tissue specific, affecting enzyme concentration in the liver but not the erythrocyte the other, which arose in a mutation experiment, doubles the enzyme concentration in both tissues. The organization and the nomenclature in the [Pk-1] gene complex are discussed and are compared with the organization of other comprehensively analysed gene complexes in the mouse.

Type
Research Article
Information
Genetics Research , Volume 58 , Issue 3 , December 1991 , pp. 233 - 241
Copyright
Copyright © Cambridge University Press 1991

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