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A lethal mutation (cab) affecting heart function in the mouse
Published online by Cambridge University Press: 14 April 2009
Summary
A new autosomal recessive gene (cab, ‘cardiac abnormality’), which affects heart differentiation appeared spontaneously in our mouse colony. The affected homozygotes die approximately half a day prior to birth or at term, with the myocardium exhibiting vacuolation and large areas of mesenchyme-like cells. A significant finding in mutant foetuses is the lack of histochemically detectable glycogen.
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- Copyright © Cambridge University Press 1979
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