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Inheritance of reaction to halothane anaesthesia in pigs

Published online by Cambridge University Press:  14 April 2009

C. Smith  and
P. R. Bampton
C. Smith
Affiliation:
A.R.C. Animal Breeding Research Organisation, West Mains Road, Edinburgh EH9 3JQ
P. R. Bampton
Affiliation:
A.R.C. Animal Breeding Research Organisation, West Mains Road, Edinburgh EH9 3JQ
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The inheritance of reaction to halothane anaesthesia (so-called malignant hyperthermia syndrome) in pigs was studied in a series of 61 litters by 18 sires from an F3–F4 Pietrain–Hampshire crossbred population. A single locus two allele model allowing for reactors from all three genotypes, was fitted by maximum likelihood. It was concluded that the reaction is due to a single autosomal recessive gene with a frequency of 0·46 (0·44–0·48) and penetrance of 0·95 (0·92–0·98) in this stock.

Type
Research Article
Information
Genetics Research , Volume 29 , Issue 3 , June 1977 , pp. 287 - 292
Copyright
Copyright © Cambridge University Press 1977

References

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