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Inheritance of P-element regulation in Drosophila melanogaster

Published online by Cambridge University Press:  14 April 2009

John D. Raymond ,
Todd A. Ojala ,
Jennifer White  and
Michael J. Simmons
John D. Raymond
Affiliation:
Department of Genetics and Cell Biology, University of Minnesota, St Paul, Minnesota 55108–1095, U.S.A.
Todd A. Ojala
Affiliation:
Department of Genetics and Cell Biology, University of Minnesota, St Paul, Minnesota 55108–1095, U.S.A.
Jennifer White
Affiliation:
Department of Genetics and Cell Biology, University of Minnesota, St Paul, Minnesota 55108–1095, U.S.A.
Michael J. Simmons*
Affiliation:
Department of Genetics and Cell Biology, University of Minnesota, St Paul, Minnesota 55108–1095, U.S.A.
*
* Corresponding author.
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Summary

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The ability to repress P-element-induced gonadal dysgenesis was studied in 14 wild-type strains of D. melanogaster derived from populations in the central and eastern United States. Females from each of these strains had a high ability to repress gonadal dysgenesis in their daughters. Reciprocal hybrids produced by crossing each of the wild-type strains with an M strain demonstrated that repression ability was determined by a complex mixture of chromosomal and cytoplasmic factors. Cytoplasmic transmission of repression ability was observed in all 14 strains and chromosomal transmission was observed in 12 of them. Genomic Southern blots indicated that four of the strains possessed a particular type of P element, called KP, which has been proposed to account for the chromosomal transmission of repression ability. However, in this study several of the strains that lacked KP elements exhibited as much chromosomal transmission of repression ability as the strains that had KP elements, suggesting that other kinds of P elements may be involved.

Type
Research Article
Information
Genetics Research , Volume 57 , Issue 3 , June 1991 , pp. 227 - 234
Copyright
Copyright © Cambridge University Press 1991

References

Bingham, P. M., Kidwell, M. G. & Rubin, G. M. (1982). The molecular basis of P–M hybrid dysgenesis: the role of the P element, a P-strain specific transposon family. Cell 29, 995–1004.CrossRefGoogle Scholar
Black, D. M., Jackson, M. S., Kidwell, M. G. & Dover, G. (1987). KP elements repress P-induced hybrid dysgenesis in D. melanogaster. EMBO Journal 6, 4125–4135.CrossRefGoogle Scholar
Daniels, S. B., Clark, S. H., Kidwell, M. G. & Chovnick, A. (1987). Genetic transformation of Drosophila melanogaster with an autonomous P element: phenotype and molecular analyses of long-established transformed lines. Genetics 115, 711–723.CrossRefGoogle ScholarPubMed
Engels, W. R. (1979 a). Hybrid dysgenesis in Drosophila melanogaster: rules of inheritance of female sterility. Genetical Research 33, 219–236.CrossRefGoogle Scholar
Engels, W. R. (1979 b). Extrachromosomal control of mutability in Drosophila melanogaster. Proceedings of the National Academy of Sciences, U.S.A. 76, 4011–4015.CrossRefGoogle ScholarPubMed
Engels, W. R. (1984). A trans-acting product needed for P factor transposition in Drosophila. Science 226, 1194–1196.CrossRefGoogle ScholarPubMed
Engels, W. R. (1989). P elements in Drosophila. In Mobile DNA (ed. Berg, D. E. and Howe, M. M.), pp. 437–484. New York: American Society for Microbiology.Google Scholar
Engels, W. R. & Preston, C. R. (1981). Characteristics of a ‘neutral’ strain in the P–M system of hybrid dysgenesis. Drosophila Information Service 56, 35–37.Google Scholar
Heath, E. M. & Simmons, M. J. (1991). Genetic and molecular analysis of repression in the P–M system of hybrid dysgenesis in Drosophila melanogaster. Genetical Research 57, 213–226CrossRefGoogle Scholar
Jackson, M. S., Black, D. S. & Dover, G. A. (1988). Amplification of KP elements associated with the repression of hybrid dysgenesis in Drosophila melanogaster. Genetics 120, 1003–1013.CrossRefGoogle ScholarPubMed
Jongeward, G., Simmons, M. & Heath, E. (1987). The instability of a P element insertion mutation is affected by chromosomes derived paternally from a pseudo-M strain of D. melanogaster. Drosophila Information Service 66, 77–80.Google Scholar
Karess, R. E. & Rubin, G. M. (1984). Analysis of P transposable element functions in Drosophila. Cell 38, 135–146.CrossRefGoogle ScholarPubMed
Kidwell, M. G. (1981). Hybrid dysgenesis in Drosophila melanogaster: the genetics of cytotype determination in a neutral strain. Genetics 98, 275–280.CrossRefGoogle Scholar
Kidwell, M. G. (1983). Evolution of hybrid dysgenesis determinants in Drosophila melanogaster. Proceedings of the National Academy in Sciences, U.S.A. 80, 1655–1659.CrossRefGoogle ScholarPubMed
Kidwell, M. G. (1985). Hybrid dysgenesis in Drosophila melanogaster: nature and inheritance of P-element regulation. Genetics 111, 337–350.CrossRefGoogle ScholarPubMed
Kidwell, M. G., Kidwell, J. F. & Sved, J. A. (1977). Hybrid dysgenesis in Drosophila melanogaster: a syndrome of aberrant traits including mutation, sterility and male recombination. Genetics 86, 813–833.CrossRefGoogle ScholarPubMed
Kocur, G. J., Drier, E. A. & Simmons, M. J. (1986). Sterility and hypermutability in the P–M system of hybrid dysgenesis in Drosophila melanogaster. Genetics 114, 1147–1163.CrossRefGoogle Scholar
Laski, F. A., Rio, D. C. & Rubin, G. M. (1986). The tissue specificity of Drosophila P element transposition is regulated at the level of mRNA splicing. Cell 44, 7–19.CrossRefGoogle ScholarPubMed
Nitasaka, E., Mukai, T. & Yamazaki, T. (1987). Repressor of P elements in Drosophila melanogaster: cytotype determination by a defective P element with only open reading frames 0 through 2. Proceedings of the National Academy of Sciences, U.S.A. 84, 7605–7608.CrossRefGoogle Scholar
O'Hare, K. & Rubin, G. M. (1983). Structure of P transposable elements in Drosophila melanogaster and their sites of insertion and excision. Cell 34, 25–35.CrossRefGoogle ScholarPubMed
Rasmusson, K. E., Simmons, M. J., Raymond, J. D. & McLarnon, C. F. (1990). Quantitative effects of P elements on hybrid dysgenesis in Drosophila melanogaster. Genetics 124, 647–662.CrossRefGoogle ScholarPubMed
Rio, D. C., Laski, F. A. & Rubin, G. M. (1986). Identification and immunochemical analysis of biologically active Drosophila P element transposase. Cell 44, 21–32.CrossRefGoogle ScholarPubMed
Robertson, H. M. & Engels, W. R. (1989). Modified P elements that mimic the P cytotype in Drosophila melanogaster. Genetics 123, 815–824.CrossRefGoogle Scholar
Simmons, M. J., Raymond, J. D., Boedigheimer, M. J. & Zunt, J. R. (1987). The influence of nonautonomous P elements on hybrid dysgenesis in Drosophila melanogaster. Genetics 117, 671–685.CrossRefGoogle ScholarPubMed
Simmons, M. J., Raymond, J. D., Laverty, T. R., Doll, R. F., Raymond, N. C., Kocur, G. J. & Drier, E. A. (1985). Chromosomal effects on mutability in the P–M system of hybrid dysgenesis in Drosophila melanogaster. Genetics 111, 869–884.CrossRefGoogle Scholar
Simmons, M. J., Raymond, J. D., Rasmusson, K. E., Miller, L. M., McLarnon, C. F. & Zunt, J. R. (1990). Repression of P-element-mediated hybrid dysgenesis in Drosophila melanogaster. Genetics 124, 663–676.CrossRefGoogle ScholarPubMed