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Inheritance of a meiosis I error expressed in mouse oocytes and modulated by a maternal factor

Published online by Cambridge University Press:  14 April 2009

Friedrich Beermann ,
Jutta Jenderny ,
Edith Hummler  and
Ingo Hansmann
Friedrich Beermann
Affiliation:
Institute of Human Genetics, University of Göttingen, Gosslerstrasse 12d, D-3400 Göttingen, FRG
Jutta Jenderny
Affiliation:
Institute of Human Genetics, University of Göttingen, Gosslerstrasse 12d, D-3400 Göttingen, FRG
Edith Hummler
Affiliation:
Institute of Human Genetics, University of Göttingen, Gosslerstrasse 12d, D-3400 Göttingen, FRG
Ingo Hansmann
Affiliation:
Institute of Human Genetics, University of Göttingen, Gosslerstrasse 12d, D-3400 Göttingen, FRG

Summary

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NMRI/Han mice ovulate significant numbers of diploid oocytes after gonadotrophin stimulation, most of them arrested at metaphase I. In contrast, females from other mouse strains ovulate only oocytes having completed meiosis I. We investigated the heritability of the trait Dipl I by analysing F1 hybrid females from crosses between the sensitive NMRI/Han stock and two mouse strains (C3H/HeHan and BALB/c) considered as non-sensitive, and females from backcrosses to NMRI/Han males (only crosses with C3H/HeHan). The results show (1) that the trait Dipl I is inheritable; (2) that an X-chromosomal (location proximally from the X–Y pairing region) or autosomal recessive mode of inheritance is excluded; and (3) that the expression of the trait, measured as frequency of diploidy, is modulated by a maternally transmitted factor.

Type
Research Article
Information
Genetics Research , Volume 49 , Issue 3 , June 1987 , pp. 239 - 243
Copyright
Copyright © Cambridge University Press 1987

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