Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-20T13:40:08.659Z Has data issue: false hasContentIssue false
  • English
  • Français

The incidence of chromosomally unbalanced gametes in T(14; 15)6 Ca heterozygote mice

Published online by Cambridge University Press:  14 April 2009

M. H. Kaufman
M. H. Kaufman
Affiliation:
Anatomy Department, Cambridge CB2 3DY, U.K.
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

When T6/+ female mice were mated to non-translocation-bearing males, the relative viability of the embryos at 13·5–14·5 days gestation was about 39%. About 36% of the oocytes ovulated by T6/+ females were aneuploid, as a result of non-disjunction at meiosis, the majority having either 19 or 21 chromosomes. However, aneuploidy only accounts for a proportion of the embryonic loss in T6/+ × +/+ matings, as many of the embryos with 41 chromosomes survive postnatally. The present findings indicate that approximately 50% of the oocytes ovulated with the normal haploid number of chromosomes (n = 20) were genetically unbalanced as a result of adjacent segregation, and that a high proportion of the resultant embryos die in the early postimplantation period. In the present study non-translocation-bearing mice which were genotypically similar to the T6/+ females acted as controls.

Type
Research Article
Information
Genetics Research , Volume 27 , Issue 1 , February 1976 , pp. 77 - 84
Copyright
Copyright © Cambridge University Press 1976

References

REFERENCES

Carter, T. C., Lyon, M. F. & Phillips, R. J. S. (1955). Gene-tagged chromosome translocations in eleven stocks of mice. Journal of Genetics 53, 154–166.CrossRefGoogle Scholar
Cattanach, B. M. (1967). A test of distributive pairing between two specific non-homologous chromosomes of the mouse. Cytogenetics 6, 67–77.CrossRefGoogle ScholarPubMed
Eicher, E. M. (1973). Translocation trisomic mice: Production by female but not male translocation carriers. Science 180, 81.CrossRefGoogle Scholar
Eicher, E. M. & Green, M. C. (1972). The T6 translocation in the mouse: its use in trosomy mapping, centromere localization and cytological identification of linkage group III. Genetics 71, 621–632.CrossRefGoogle Scholar
Forejt, J. (1974). Nonrandom association between a specific autosome and the X chromosome in meiosis of the male mouse: possible consequence of the homologous centromeres' separation. Cytogenetics and Cell Genetics 13, 369–383.CrossRefGoogle Scholar
Kaufman, M. H. & Sachs, L. (1975). The early development of haploid and aneuploid parthenogenetic embryos. Journal of Embryology and Experimental Morphology 34, 645–655.Google ScholarPubMed
Lyon, M. F. & Meredith, R. (1966). Autosomal translocation causing male sterility and viable aneuploidy in the mouse. Cytogenitics 5, 335–354.CrossRefGoogle ScholarPubMed
Miller, O. J., Miller, D. A., Kouri, R. E., Allderdice, P. W., Dev, V. G., Grewal, M. S. & Hutton, J. J. (1971). Identification of the mouse karyotype by quinacrine fluorescence and tentative assignment of seven linkage groups. Proceedings of the National Academy of Sciences 68, 1530–1533.CrossRefGoogle ScholarPubMed
Nesbitt, M. N. & Francke, U. (1971). Analysis of the T (3;?)6 Ca and T (14;17)264 Ca translocations in the mouse by quinacrine mustard staining. Genetics 69, 517–522.CrossRefGoogle Scholar
Oshimura, M. & Takagi, N. (1975). Meiotic disjunction in T(14:15)6 Ca heterozygotes and fate of chromasomally unbalanced gametes in embryonic development. Cytogenetics and Cell Genetics 15, 1–16.CrossRefGoogle Scholar
Snell, G. D. (1946). An analysis of translocations in the mouse. Genetics 31, 157–180.CrossRefGoogle ScholarPubMed
Snell, G. D., Bodemann, E. & Hollander, W. (1934). A translocation in the house mouse and its effect on development. Journal of Experimental Zoology 67, 93–104.CrossRefGoogle Scholar
Tarkowski, A. K. (1966). An air-drying method for chromosome preparations from mouse eggs. Cytogenetics 5, 394–400.CrossRefGoogle Scholar