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How pure are our inbred strains of mice?

Published online by Cambridge University Press:  14 April 2009

M. S. Deol ,
H. Grüneberg ,
A. G. Searle  and
G. M. Truslove
M. S. Deol
Affiliation:
Medical Research Council Group for Experimental Research in Inherited Diseases, University College, London
H. Grüneberg
Affiliation:
Medical Research Council Group for Experimental Research in Inherited Diseases, University College, London
A. G. Searle
Affiliation:
Medical Research Council Group for Experimental Research in Inherited Diseases, University College, London
G. M. Truslove
Affiliation:
Medical Research Council Group for Experimental Research in Inherited Diseases, University College, London
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Sixty-six individual tests on an array of skeletal variants showed an essential absence of parent-offspring correlations in the inbred strains C57BL, A and CBA in the mouse. It is concluded that these strains, and inbred strains of mice in general, are genetically homogeneous except for the differentiation of genetically distinct sublines as the result of mutations.

Type
Research Article
Information
Genetics Research , Volume 1 , Issue 1 , February 1960 , pp. 50 - 58
Copyright
Copyright © Cambridge University Press 1960

References

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