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Histocompatibility mutations in mice: chemical induction and linkage with the H-2 locus

Published online by Cambridge University Press:  14 April 2009

I. K. Egorov  and
Zinaida K. Blandova
I. K. Egorov
Affiliation:
Institute of General Genetics of the Academy of Sciences, Moscow, and Laboratory of Experimental Animals of the Academy of Medical Sciences, Moscow Region, U.S.S.R.
Zinaida K. Blandova
Affiliation:
Institute of General Genetics of the Academy of Sciences, Moscow, and Laboratory of Experimental Animals of the Academy of Medical Sciences, Moscow Region, U.S.S.R.
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Young mice of the strains A/Y and B10.D2 were repeatedly treated with diethylsulphate (DES) in different doses (36 to 1100 mg/kg). At the age of 9 weeks they were mated to females of the strains A. CA (‘A’ group) and C57BL/10Eg (‘D’ group) respectively. 2101 progeny of these matings were tested for histocompatibility by skin grafting. The spontaneous H-mutation rates were 6·96 × 10−4 per gamete in the A group and 9·6 × 10−4 per gamete in D group. In progeny of treated males the H-mutation rates were 0 in A group and 5·79 × 10−3 per gamete in D group, showing apparent effect of paternal DES treatment on mutation frequency in the last group. Two mutations of the H-2 locus were found, which together with the other three H-2 mutations published so far yielded a mutation rate of 5·18 × 10−4 per gamete. The mutation rate of the H-2 locus is higher than the expected rate per H-locus, indicating a great genetic complexity of H-2.

Type
Research Article
Information
Genetics Research , Volume 19 , Issue 2 , April 1972 , pp. 133 - 143
Copyright
Copyright © Cambridge University Press 1972

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