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High genetic variability under the balance between symmetric mutation and fluctuating stabilizing selection

Published online by Cambridge University Press:  14 April 2009

Alexey S. Kondrashov  and
Lev Yu. Yampolsky
Alexey S. Kondrashov*
Affiliation:
Section of Ecology and Systematics, Cornell University, Ithaca, NY 14853, USA
Lev Yu. Yampolsky
Affiliation:
Section of Ecology and Systematics, Cornell University, Ithaca, NY 14853, USA
*
*Corresponding author. Telephone: +1(607) 254-4221. Fax: + 1(607) 255-8088. e-mail: [email protected].

Summary

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We have studied variability maintained in a quantitative trait by the balance between symmetric mutation and direct stabilizing selection with a fluctuating optimum. Using a simulational computer model, we have found that wide fluctuations, such that the range of the optimum changes exceeds the width of the fitness curve, increase the trait variance, often by two or three orders of magnitude, over its value under constant selection. This happens because such fluctuations cause frequent allele substitutions at the loci that control the trait. At any particular moment the variance is increased mostly due to one or several loci where more than one allele is currently common. The data on fluctuating selection in nature are reviewed

Type
Research Article
Information
Genetics Research , Volume 68 , Issue 2 , October 1996 , pp. 157 - 164
Copyright
Copyright © Cambridge University Press 1996

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