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The genetics of some second chromosome melanotic tumour mutants of Drosophila melanogaster

Published online by Cambridge University Press:  14 April 2009

John C. Sparrow
John C. Sparrow
Affiliation:
School of Biological Sciences, University of Sussex, Brighton
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Summary

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The genetic relationships of the available second chromosome melanotic tumour mutants in Drosophila melanogaster have been investigated. Complementation tests demonstrate the existence of new alleles of the tu bw locus and show that tu-W and tu-g are alleles. The data suggest that there is a minimum of three major gene loci on the second chromosome involved in tumorigenesis. A number of modifier genes were found which affect the penetrance of the major tumour genes analysed. These and the problems they cause in mapping the low penetrant tumour genes are discussed. It has not been possible to map tu-48a, tu- W and tu-g accurately, due largely to the presence of modifier genes. It appears that the genetic basis for melanotic tumour formation is complex.

Type
Research Article
Information
Genetics Research , Volume 23 , Issue 1 , February 1974 , pp. 13 - 21
Copyright
Copyright © Cambridge University Press 1974

References

REFERENCES

Barigozzi, C. (1968). Genetic control of melanotic tumours in Drosophila. National Cancer Institute Monograph 31, 227–290.Google Scholar
Burdette, W. J. (1959). Tumors in Drosophila. Texas University Publication, no. 5914, pp. 57–68.Google Scholar
Burnet, B. (1966). Allelism of tumour genes. Drosophila Information Service 41, 161.Google Scholar
Burnet, B. & Sang, J. H. (1964). Physiological genetics of tumours in Drosophila melanogaster. II. The genetic basis of response to tumorigenic treatments in tuK and tu bw; st su-tu strains. Genetics 49, 599–610.CrossRefGoogle Scholar
Erk, F. C. & Sang, J. H. (1966). Allelism of second chromosome melanotic tumour genes. Drosophila Information Service 41, 95.Google Scholar
Ghelelovitch, S. (1958). Une tumeur héréditaire de la Drosophile (Drosophila melanogaster, Meig.). Eutude génétique et physiologique. Biologic medicale (Paris) 48, 52–97.Google Scholar
Glass, B. (1957). In pursuit of a gene. Science 126, 683–689.CrossRefGoogle ScholarPubMed
Harshbarger, J. C. & Taylor, R. L. (1968). Neoplasms of insects. Annual Review of Entomology 13, 159–190.CrossRefGoogle Scholar
Herskowitz, I. H. & Burdette, W. J. (1951). Some of the genetic and environmental influences on the incidence of a melanotic tumour in Drosophila. Journal of Zoology 117, 499–522.Google Scholar
Kojima, K. & Dalebroux, M. (1965). A procedure for analysing three-point test data when one gene shows low penetrance. Drosophila Information Service 34, 51.Google Scholar
Lewis, E. B. (1960). A new standard food medium. Drosophila Information Service 34, 117–118.Google Scholar
Lindsley, D. L. & Grell, E. H. (1968). Genetic variations of Drosophila melanogaster. Carnegie Institute of Washington Publication, no. 627.Google Scholar
Rizki, T. M. (1960). Melanotic tumour formation in Drosophila. Journal of Morphology 106, 147–157.CrossRefGoogle Scholar
Sang, J. H. (1963). Penetrance, expressivity and thresholds. Journal of Heredity 54, 143–151.Google Scholar
Sang, J. H. (1966). Clearing of Drosophila adults. Drosophila Information Service 41, 200.Google Scholar
Sang, J. H. (1968). Biochemical basis of hereditary melanotic tumours in Drosophila. National Cancer Institute Monograph 31, 291–301.Google Scholar
Sang, J. H. & Burnet, B. (1963). Physiological genetics of melanotic tumors in Drosophila melanogaster. I. The effects of nutrient balance on tumour penetrance in the tuK strain. Genetics 48, 235–253.Google Scholar
Sang, J. H. & Burnet, B. (1967). Physiological genetics of melanotic tumours in Drosophila melanogaster. IV. Gene-environment interactions of the tu bw with different third chromosome backgrounds. Genetics 56, 743–754.CrossRefGoogle Scholar
Wilson, L. P., King, R. C. & Lowry, J. L. (1955). Studies on the tu-W strain of Drosophila melanogaster. I. Phenotypic and genotypic characterisation. Growth 19, 215–244.Google Scholar