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The genetics of Sleek: a possible regulatory mutation of the tabby-crinkled-downless syndrome

Published online by Cambridge University Press:  14 April 2009

Mark Crocker  and
Bruce M. Cattanach
Mark Crocker
Affiliation:
MRC Radiobiology Unit, Harwell, Oxon.
Bruce M. Cattanach
Affiliation:
MRC Radiobiology Unit, Harwell, Oxon.
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Summary

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A new mutation, Sleek, similar in appearance to mutations at the Ta, cr and dl loci, has been investigated. It is inherited as an autosomal dominant and maps very close to dl on chromosome 13. Allelism with dl seems probable since Sleek interacts with dl but not with cr. The unusual occurrence of dominant and recessive alleles at the same locus which produce a similar mutant phenotype suggests that the locus might either code for a multimeric protein or a regulatory product.

Type
Research Article
Information
Genetics Research , Volume 34 , Issue 3 , December 1979 , pp. 231 - 238
Copyright
Copyright © Cambridge University Press 1979

References

REFERENCES

Beckwith, J. & Rossow, P. (1974). Analysis of genetic regulatory mechanisms. Annual Review of Genetics 9, 1–13.CrossRefGoogle Scholar
Britten, R. J. & Davidson, E. H. (1969). Gene regulation for higher cells: a theory. Science 165, 349–357.CrossRefGoogle ScholarPubMed
Cattanach, B. M. (1975). Mouse News Letter 53, 29.Google Scholar
Dun, R. B. & Fraser, A. S. (1959). Selection for an invariant character, vibrissa number in the house mouse. Australian Journal of Biological Science 12, 506–523.CrossRefGoogle Scholar
Falconer, D. S. (1953). Total sex linkage in the house mouse. Zeitschrift für induktive Abstammungs- und Vererbungslehre 85, 210–219.Google ScholarPubMed
Falconer, D. S., Fraser, A. S. & King, J. W. B. (1951). The genetics and development of ‘crinkled’ a new mutant in the house mouse. Journal of Genetics 50, 324–344.CrossRefGoogle ScholarPubMed
Hagen, D. C., Lipton, P. J. & Magasanik, B. (1974). Isolation of a raws-dominant histidasenegative mutant of Salmonella typhimurium. Journal of Bacteriology 120, 906–916.CrossRefGoogle ScholarPubMed
Grüneburg, H. (1971). The tabby syndrome in the mouse. Proceedings of the Royal Society of London B 179, 139–156.Google Scholar
Kacser, H. & Burns, J. A. (1973). The control of flux. In Rate control of Biological Processes. Symposium of the Society for Experimental Biology, no. XXVII, pp. 65–104.Google Scholar
Kindred, B. (1967). Some observations on the skin and hair of Tabby mice. Journal of Heredity 58, 197–199.CrossRefGoogle Scholar
Phillips, R. J. S. (1960.) Private communication. Mouse News Letter 23, 29.Google Scholar
Sofaer, J. A. (1969 a). Aspects of the tabby–crinkled–downless syndrome. I. The development of tabby teeth. Journal of Embryology and Experimental Morphology 22, 181–205.Google ScholarPubMed
Sofaer, J. A. (1969 b). Aspects of the tabby–crinkled–downless syndrome. II. Observations on the reaction to changes of genetic background. Journal of Embryology and Experimental Morphology 22, 207–227.Google ScholarPubMed
Sofaer, J. A. (1977). The teeth of the ‘Sleek’ mouse. Archives of oral Biology 22, 299–301.CrossRefGoogle ScholarPubMed