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Genetically determined organ specific responses to the teratogenic action of 6-aminonicotinamide in the mouse†

Published online by Cambridge University Press:  14 April 2009

Marc Goldstein ,
Merrille Feiner Pinsky  and
F. C. Fraser
Marc Goldstein
Affiliation:
Department of Genetics, McGill University, Montreal, Canada
Merrille Feiner Pinsky
Affiliation:
Department of Genetics, McGill University, Montreal, Canada
F. C. Fraser
Affiliation:
Department of Genetics, McGill University, Montreal, Canada
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1. A two-hour relative deficiency of nicotinamide, produced by maternal treatment with 6-aminonicotinamide, resulted in a maximum frequency of vertebral fusions following treatment on day 9·5 of gestation, and a maximum frequency of cleft palates following treatment on day 13·5.

2. Both defects appeared with higher frequencies in the A/Jax than in the C57BL/6J inbred strain.

3. The frequency of induced vertebral fusions in F1 embryos from crosses between the strains was higher when the father was from the A/Jax strain than when the mother was—a patroclinous reciprocal cross difference.

4. The frequency of induced cleft palate in F1 embryos from crosses between the strains was higher when the mother was from the A/Jax strain than when the father was—a matroclinous reciprocal cross difference.

5. Since the reciprocal cross differences in frequency of vertebral fusions and for cleft palates were in opposite directions, the hereditary factors influencing susceptibility to the teratogen appear to differ for the respective organ anlage. These differences appear to be, in part, cytoplasmic.

6. The frequency of induced cleft palate in the offspring of backcrosses of (untreated) F1 female hybrids to A/Jax males differed according to the cytoplasmic origin of the F1 mothers. Thus the susceptibility of an embryo to the teratogen appears to be influenced by factors transmitted through the cytoplasm.

Type
Research Article
Information
Genetics Research , Volume 4 , Issue 2 , July 1963 , pp. 258 - 265
Copyright
Copyright © Cambridge University Press 1963

References

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