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Genetical and embryological studies of the jt form of syndactylism in the mouse

Published online by Cambridge University Press:  14 April 2009

Elizabeth M. Center
Elizabeth M. Center
Affiliation:
Department of Anatomy, Stanford University School of Medicine, Stanford, California, U.S.A.
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1. A form of syndactylism (jt) involving two or three digits on one or more feet has been found in the descendants of Swiss-albino mice treated with HN2. The fusions are in a proximo-distal direction and usually involve only the skin and soft tissues; digits 1 and 5 are unaffected.

2. This type of syndactylism is apparently due to a single recessive gene, jt, whose penetrance is influenced by ‘genetic background’. Apparently the identical mutation has occurred independently in stock maintained at Bar Harbor and Stanford. Linkage tests indicate that jt is not linked with c or lu.

3. Embryological studies of the developing footplate reveal a loss in both preaxial and postaxial footplate tissue, primarily the latter, prior to and during the condensation of mesenchyme into the precartilage of the digital elements in the jt/jt limb.

4. The importance of the shape and amount of footplate tissue to the resultant morphology of the foot is apparent. It is evident that genes such as jt are responsible for changes in footplate development, but the immediate underlying factors which cause these alterations remain an unsolved problem.

Type
Research Article
Information
Genetics Research , Volume 8 , Issue 1 , August 1966 , pp. 33 - 40
Copyright
Copyright © Cambridge University Press 1966

References

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