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Genetic variation between mice in their metabolism of coumarin and its derivatives

Published online by Cambridge University Press:  14 April 2009

I. E. Lush  and
Kathryn M. Andrews
I. E. Lush
Affiliation:
Department of Genetics, Royal Free Hospital School of Medicine, 8 Hunter Street, London WC1N 1BP
Kathryn M. Andrews
Affiliation:
Department of Genetics, Royal Free Hospital School of Medicine, 8 Hunter Street, London WC1N 1BP

Summary

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Adult females from 19 strains of mice were injected with either coumarin or 7-ethoxycoumarin and the urinary excretion of the umbelliferone produced by the metabolism of these substances was measured. With the exception of C57L the strains fell into three classes as follows: high metabolizers (DBA/1 and DBA/2), medium metabolizers (CBA, 129/Rr, NZB and NZW) and low metabolizers (the other 12 strains). The difference in metabolizing ability between the medium group and the low group of strains was also evident when the 4-methyl derivatives of the same two substances were used. However with the 4-methyl derivatives there was no difference in metabolizing ability between the medium group and the high group. The results are interpreted as evidence that the gene Coh on chromosome 7 comprises two closely linked genes which determine cytochrome P-450 isozymes with different substrate specificities.

Type
Research Article
Information
Genetics Research , Volume 31 , Issue 2 , April 1978 , pp. 177 - 186
Copyright
Copyright © Cambridge University Press 1978

References

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